1192352-34-3Relevant academic research and scientific papers
Highly selective recognition of a-chiral primary organoammonium ions by C3-symmetric peptide receptors
Schnopp, Markus,Haberhauer, Gebhard
, p. 4458 - 4467 (2009)
A straightforward synthesis of C3-symmet:ric, imidazole-containing, macrocyclic peptides with different binding arms is presented, The chirality of the backbone and the selection of adequate receptor arms make these systems highly selective receptors for α-chiral primary organoammonium ions. Furthermore, the receptors have the ability to discriminate between enantiomeric guests with selectivity ratios of up to 87:13, The binding constants and the selectivity ratios were estimated by standard 1H NMR titration techniques in CDCl3.
BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS
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Page/Page column 60, (2011/02/24)
The present invention relates to benzoxazinone derivatives, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in treating disorders mediated by GlyT1, including neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder.
