119239-00-8Relevant academic research and scientific papers
Electronic control of enantioselectivity in the palladium-catalyzed asymmetric allylic substitution of trans 4-tbutyl-1-vinylcyclohexyl benzoates
Legros,Fiaud
, p. 465 - 474 (2007/10/02)
The enantioselectivity in the palladium-catalyzed substitution of allylic benzoates I by sodium dimethylmalonate was influenced by polar and steric effects of the substituents in the phenyl ring of the benzoate. Electron- donating p-substituents afforded
Substrate Leaving Group Control of the Enantioselectivity in the Palladium-Catalyzed Asymmetric Allylic Substitution of 4-Alkyl-1-vinylcyclohexyl Derivatives
Fiaud, Jean-Claude,Legros, Jean-Yves
, p. 4840 - 4846 (2007/10/02)
The strong influence of the nature of the leaving group in allylic derivatives in their enantioselective Pd-catalyzed substitution by nucleophile is reported.Analysis of the stereochemical course of the Pd-catalyzed substitution of achiral trans-4-tert-bu
Palladium-catalyzed asymmetric synthesis of axially chiral molecules
Fiaud, J. C.,Legros, J. Y.
, p. 383 - 396 (2007/10/02)
The asymmetric synthesis of chiral 3-alkylidene bicyclooctane and 4-substituted 1-alkylidene cyclohexane systems has been carried out (in up to 40percent ee) by the palladium-catalyzed reaction of allylic acetates with sodium dimethyl malonate or m
PALLADIUM-CATALYZED ASYMMETRIC SYNTHESIS OF AXIALLY DISSYMMETRIC 4-t-BUTYL-ALKYLIDENECYCLOHEXANE DERIVATIVE
Fiaud, J. C.,Legros, J. Y.
, p. 2959 - 2962 (2007/10/02)
Cis- and trans-4-tert-butyl-1-vinylcyclohexyl acetates gave optically active ( up to 40 percent ee) dimethyl 2-(4-tert-butylcyclohexylidene)methylmalonate through Pd-catalyzed reaction of sodium dimethylmalonate in the presence of chiral phosphines.
