119244-91-6

Upstream product

• 501-53-1 benzyl chloroformate 
• 616-29-5 1,3-Diamino-2-hydroxypropane 

Downstream Products

• 678166-63-7 2-(benzyloxycarbonyl)amino-1-(benzyloxycarbonyl)aminomethylethyl thioacetate 
• 247102-06-3 bis-N-benzyloxycarbonyl-2-fluoro-1,3-diaminopropane 
• 119244-94-9 O-acetyl-N,N'-bis(carbobenzyloxy)-2,3-diaminopropan-1-ol 
• 105655-80-9 3,4-butyronitrile 
• 119244-93-8 N,N'-bis(carbobenzyloxy)-2-(aminomethyl)aziridine 
• 54798-70-8 N,N'-bis(carbobenzyloxy)-2,3-diaminopropan-1-ol 
• 119244-95-0 N,N'-bis(carbobenzyloxy)-1,2-diamino-3-chloropropane 
• 213475-67-3 [2-benzyloxycarbonylamino-1-(benzyloxycarbonylaminomethyl)ethyl]carbamic acid tert-butyl ester 
• 213475-65-1 [2-amino-3-(benzyloxycarbonylamino)propyl]carbamic acid benzyl ester 
• 159638-09-2 [2-azido-3-(benzyloxycarbonylamino)propyl]carbamic acid benzyl ester 
• 119244-92-7 methanesulfonic acid 2-benzyloxycarbonylamino-1-(benzyloxycarbonylaminomethyl)-ethyl ester 

Relevant academic research and scientific papers

Development of a chemoenzymatic strategy for the synthesis of optically active and orthogonally protected polyamines

The chemical preparation and stereoselective enzymatic desymmetrization of a series of prochiral 2-substituted-1,3-propanediamines have been carried out using Pseudomonas cepacia lipase as biocatalyst. Syntheses of novel optically active orthogonally protected di- or triamines have been achieved for the first time with different grade of enantiodiscrimination depending on the C-2 substitution of the propane-1,3-diamine fragment. Final monoselective deprotection reactions of (S)-3-allyl-2-tert-butyl-1-(9-fluorenylmethyl)propane-1,2,3-triyltriscarbamate have allowed us to obtain a panel of novel enantiomerically enriched disubstituted triamines, compounds of difficult access by conventional synthetic methods.

2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors

New analogues of 2-[2-substituted-3-(3,4-dichlorobenzylamino)propylamino]quinolin-4-ones, 26a, 26b, 31a-e, 34, 35, 38 and 40, have been synthesized and evaluated against Staphylococcus aureus methionyl-tRNA synthetase. All of the synthesized compounds were less active than the reference compound 2. The compounds were also screened against various strains of S. aureus and Enterococci for their antibacterial activities. Among the compounds, 26b, 31c and 31e displayed significant inhibitory properties against various strains of Enterococci compared to compound 2.

A General Route to the Synthesis of N-Protected 1-Substituted and 1,2-Disubstituted Taurines

N-Benzyloxycarbonyl protected α-substituted and αβ- disubstituted taurines were synthesized from olefins and epoxides via N-benzyloxycarbonylamino alcohol thioacetates as key intermediates. They are important sulfur analogues of naturally occurring amino acids and building blocks for the synthesis of α-substituted and α,β- disubstituted β-sulfonopeptides.

A Convenient Synthesis of Vicinal Diamines

Various 3-substituted-1,2-diaminopropane compounds in which the amino groups are protected as bis(carbamates) or bis(sulfonamides) were prepared from the corresponding N,N'-bis-protected 2-(aminomethyl)aziridine derivatives by nucleophilic opening of the aziridine ring.The aziridine derivatives are ultimately derived from readily available 2-hydroxy-1,3-diaminopropane.A variety of nucleophiles can be added to incorporate various functionality (CN, O2CCH3, OH, Cl, CH3, CH2CO2H) in the 3-position of the resulting 1,2-diaminopropane derivatives.