1192469-25-2Relevant academic research and scientific papers
Dual Reactivity of 1,2,3,4-Tetrazole: Manganese-Catalyzed Click Reaction and Denitrogenative Annulation
Chattopadhyay, Buddhadeb,Das, Sandip Kumar,Khatua, Hillol,Roy, Satyajit
, p. 304 - 312 (2021)
A general catalytic method using a Mn-porphyrin-based catalytic system is reported that enables two different reactions (click reaction and denitrogenative annulation) and affords two different classes of nitrogen heterocycles, 1,5-disubstituted 1,2,3-triazoles (with a pyridyl motif) and 1,2,4-triazolo-pyridines. Mechanistic investigations suggest that although the click reaction likely proceeds through an ionic mechanism, which is different from the traditional click reaction, the denitrogenative annulation reaction likely proceeds via an electrophilic metallonitrene intermediate rather than a metalloradical intermediate. Collectively, this method is highly efficient and offers several advantages over other methods. For example, this method excludes a multi-step synthesis of the N-heterocyclic molecules described and produces only environmentally benign N2 gas a by-product.
Synthetic method 1, 2 and 4 - triazole compound
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Paragraph 0090-0093, (2021/12/07)
The invention discloses 1. 2,4 - Triazole compound synthesis method belongs to the technical field of synthesis of triazole compounds. After the reaction is finished, the reaction is carried out under the heating condition, and the target product 1, 2 and
Method for electrochemically synthesizing 1, 2 and 4 - triazole compounds
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Paragraph 0022-0037; 0046-0049, (2020/10/20)
The invention discloses a method of electrochemically synthesizing a 1, 2, 4-triazole compound. The method includes: dissolving a compound (I) and quaternary ammonium salt into acetonitrile, stirringat room temperature of 50 DEG C to obtain reaction liqui
PhI(OAc) 2 -Mediated Regioselective Synthesis of 5-Guanidino-1,2,4-thiadiazoles and 1,2,4-Triazolo[1,5- a ]pyridines via Oxidative N-S and N-N Bond Formation
Krishna, Palakodety Radha,Mangarao, Nakka,Nagaraju, Tumula,Sridhar, Balasubramanian
, p. 3600 - 3610 (2019/09/30)
An effective and expeditious approach for the construction of biologically important 5-guanidino-1,2,4-thiadiazole and 1,2,4-triazolo[1,5- a ]pyridine derivatives has been developed. This new protocol involves the phenyliodine(III) diacetate [PhI(OAc) su
Intramolecular electrochemical dehydrogenative N-N bond formation for the synthesis of 1,2,4-triazolo[1,5-a] pyridines
Li, Yong,Ye, Zenghui,Chen, Na,Chen, Zhenkun,Zhang, Fengzhi
supporting information, p. 4035 - 4039 (2019/08/07)
A metal- and oxidant-free intramolecular dehydrogenative N-N bond formation has been developed under mild and scalable electrolytic conditions. Various valuable 1,2,4-triazolo[1,5-a]pyridines were synthesized efficiently from the readily available N-(2-pyridyl)amidines. The reactions were conducted in a simple undivided cell under constant current conditions with nBu4NBr as both the redox mediator and the electrolyte. This protocol was applied to the efficient synthesis of key intermediates for anti-diabetic compounds.
PhI(OCOCF3)2-mediated intramolecular oxidative N-N bond formation: Metal-free synthesis of 1,2,4-triazolo[1,5-a]pyridines
Zheng, Zisheng,Ma, Shuangyu,Tang, Linlin,Zhang-Negrerie, Daisy,Du, Yunfei,Zhao, Kang
, p. 4687 - 4693 (2014/06/09)
The biologically important 1,2,4-triazolo[1,5-a]pyridines were readily synthesized from N-(pyridin-2-yl)benzimidamides via phenyliodine bis(trifluoroacetate)-mediated intramolecular annulation. This novel strategy allows for the convenient construction of a 1,2,4-triazolo[1,5-a]pyridine skeleton through direct metal-free oxidative N-N bond formation, featuring a short reaction time and high reaction yields.
