1192490-96-2Relevant articles and documents
Further studies on arylpiperazinyl alkyl pyridazinones: Discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain
Biancalani, Claudio,Giovannoni, Maria Paola,Pieretti, Stefano,Cesari, Nicoletta,Graziano, Alessia,Vergelli, Claudia,Cilibrizzi, Agostino,Di Gianuario, Amalia,Colucci, Mariantonella,Mangano, Giorgina,Garrone, Beatrice,Polenzani, Lorenzo,Dal Piaz, Vittorio
experimental part, p. 7397 - 7409 (2010/06/13)
A number of pyridazinone derivatives bearing an arylpiperazinylalkyl chain were synthesized and tested icv in a model of acute nociception induced by thermal stimuli in mice (tail flick). The most interesting and potent compound in this series was 6a, whi