1192690-71-3Relevant academic research and scientific papers
Divergent synthesis of (6S,1′S,2′R)-hydroxypestalotin via tandem conjugate addition-lactonization sequence
Mallula, Venkata Satyanarayana,Srinivas, Batthula,Radha Krishna, Palakodety
, p. 1115 - 1117 (2015)
The stereoselective synthesis of (6S,1′S,2′R)-hydroxypestalotin from trans-hex-2-en-1-ol utilizing asymmetric dihydroxylation and Luche's reduction and tandem conjugative addition-lactonization as the key steps is reported.
First stereoselective total synthesis and anticancer activity of new amide alkaloids of roots of pepper
Srinivas,Sai Pavan Kumar,China Raju,Jayathirtha Rao,Naidu,Ramakrishna,Diwan, Prakash V.
scheme or table, p. 5915 - 5918 (2010/04/29)
The first stereoselective total synthesis of new natural amide alkaloids 1-3 have been achieved from commercially available starting materials. Wittig olefination, Sharpless asymmetric dihydroxylation, epoxidation, a trans regioselective opening of 2,3-epoxy alcohol, Horner-Wadsworth-Emmons (HWE) olefination and amide coupling are the key steps. The amide alkaloids 1-3 are evaluated for their anticancer activity against colon (HT-29), breast (MCF-7) and lung (A-549) human cancer cell lines for the first time.
