1192711-71-9

Basic information

• Product Name: 2,4-Dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine
• Synonyms: 2,4-Dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine;2,4-Dichloro-6-methyl-7H-...;7H-Pyrrolo[2,3-d]pyriMidine,2,4-dichloro-6-Methyl-
• CAS NO: 1192711-71-9
• Molecular Formula: C₇H₅Cl₂N₃
• Molecular Weight: 202.0407
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 1192711-71-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.572±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.85±0.50(Predicted)
• CAS DataBase Reference: 2,4-Dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine(1192711-71-9)
• EPA Substance Registry System: 2,4-Dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine(1192711-71-9)

Safety Data

• Hazardous Substances Data: 1192711-71-9(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine is a chemical compound with a molecular formula C7H5Cl2N3. It is a pyrrolopyrimidine derivative with two chlorine atoms and one methyl group attached to the pyrimidine ring. 2,4-Dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine has been studied for its potential use as a pharmaceutical intermediate and is known for its structural and biological activity. Its unique structure and properties make it a valuable compound for research and development of new drugs and chemical processes.

Upstream product

• 89792-20-1 6-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diol 

Downstream Products

• 1116240-25-5 2,4-dichloro-6-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 
• 1355173-69-1 2-((2-((R)-3-aminopiperidin-1-yl)-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)methyl)benzonitrile 
• 1355174-84-3 2-((2-chloro-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)methyl)benzonitrile 

Relevant articles and documents

Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents

Focal adhesion kinase (FAK) is a ubiquitous intracellular non-receptor tyrosine kinase, which is involved in multiple cellular functions, including cell adhesion, migration, invasion, survival, and angiogenesis. In this study, a series of 7H-pyrrolo[2,3-d

Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization

We previously reported a highly potent DPP-IV inhibitor 6 with low in vivo efficacy. While trying to maintain consistent in vitro and in vivo biological activity, we initiated a pharmacokinetic property-driven optimization to improve the metabolic stability and permeability of inhibitor 6. A simple scaffold replacement of thienopyrimidine with pyrrolopyrimidine (21a) led to significantly improved metabolic stability (4% vs. 65% remaining). Further modification of the pyrrolopyrimidine scaffold to produce compound 21j resulted in much better oral bioavailability than 6. Importantly, compound 21j exhibits greater in vivo efficacy than does 6 and Alogliptin and is worthy of further development.