1192807-15-0Relevant academic research and scientific papers
Design and Synthesis of a New Series of 4-Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship
Cook, James,Zusi, F. Christopher,McDonald, Ivar M.,King, Dalton,Hill, Matthew D.,Iwuagwu, Christiana,Mate, Robert A.,Fang, Haiquan,Zhao, Rulin,Wang, Bei,Cutrone, Jingfang,Ma, Baoqing,Gao, Qi,Knox, Ronald J.,Matchett, Michele,Gallagher, Lizbeth,Ferrante, Meredith,Post-Munson, Debra,Molski, Thaddeus,Easton, Amy,Miller, Regina,Jones, Kelli,Digavalli, Siva,Healy, Francine,Lentz, Kimberley,Benitex, Yulia,Clarke, Wendy,Natale, Joanne,Siuciak, Judith A.,Lodge, Nicholas,Zaczek, Robert,Denton, Rex,Morgan, Daniel,Bristow, Linda J.,Macor, John E.,Olson, Richard E.
, p. 11171 - 11181 (2016)
The design and synthesis of a series of quinuclidine-containing spirooxazolidines ("spiroimidates") and their utility as α7 nicotinic acetylcholine receptor partial agonists are described. Selected members of the series demonstrated excellent selectivity
Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.
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, (2018/10/03)
PROBLEM TO BE SOLVED: To provide ligands for the nicotinic α-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.
QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
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Page/Page column 77, (2011/05/11)
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
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Page/Page column 59, (2009/10/31)
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
