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1192814-45-1

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1192814-45-1 Usage

General Description

6-Amino-2,3-dichloropyridine is a complex organic compound that belongs to the family of pyridines. It is an aminopyridine in which a nitrogen atom is also substituted by an amino group at the place of hydrogen in the pyridine ring. 6-Amino-2,3-dichloropyridine also includes two chlorine atoms, hence the prefix "dichloro" is included in its name. The chemical formula of this compound is C5H4Cl2N2. Like other pyridines, it has several derivatives and plays a significant role in pharmaceutical and organic chemistry. Its uses and impacts largely depend on its concentration and chemical surroundings. It should be handled with care since its impact on health or the environment is not fully understood yet.

Check Digit Verification of cas no

The CAS Registry Mumber 1192814-45-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,2,8,1 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1192814-45:
(9*1)+(8*1)+(7*9)+(6*2)+(5*8)+(4*1)+(3*4)+(2*4)+(1*5)=161
161 % 10 = 1
So 1192814-45-1 is a valid CAS Registry Number.

1192814-45-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,6-dichloropyridin-2-amine

1.2 Other means of identification

Product number -
Other names 6-Amino-2,3-dichloropyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1192814-45-1 SDS

1192814-45-1Relevant articles and documents

GluN2A-selective pyridopyrimidinone series of nmdar positive allosteric modulators with an improved in vivo profile

Villemure, Elisia,Volgraf, Matthew,Jiang, Yu,Wu, Guosheng,Ly, Cuong Q.,Yuen, Po-Wai,Lu, Aijun,Luo, Xifeng,Liu, Mingcui,Zhang, Shun,Lupardus, Patrick J.,Wallweber, Heidi J. A.,Liederer, Bianca M.,Deshmukh, Gauri,Plise, Emile,Tay, Suzanne,Wang, Tzu-Ming,Hanson, Jesse E.,Hackos, David H.,Scearce-Levie, Kimberly,Schwarz, Jacob B.,Sellers, Benjamin D.

, p. 84 - 89 (2016)

The N-methyl-D-aspartate receptor (NMDAR) is an ionotropic glutamate receptor, gated by the endogenous coagonists glutamate and glycine, permeable to Ca2+ and Na+. NMDAR dysfunction is associated with numerous neurological and psychiatric disorders, including schizophrenia, depression, and Alzheimer's disease. Recently, we have disclosed GNE-0723 (1), a GluN2A subunit-selective and brain-penetrant positive allosteric modulator (PAM) of NMDARs. This work highlights the discovery of a related pyridopyrimidinone core with distinct structure-activity relationships, despite the structural similarity to GNE-0723. GNE-5729 (13), a pyridopyrimidinone-based NMDAR PAM, was identified with both an improved pharmacokinetic profile and increased selectivity against AMPARs. We also include X-ray structure analysis and modeling to propose hypotheses for the activity and selectivity differences.

Synthesis of new imidazopyridine nucleoside derivatives designed as maribavir analogues

Papadakis, Georgios,Gerasi, Maria,Snoeck, Robert,Marakos, Panagiotis,Andrei, Graciela,Lougiakis, Nikolaos,Pouli, Nicole

, (2020/10/18)

The strong inhibition of Human Cytomegalovirus (HCMV) replication by benzimidazole nucleosides, like Triciribine and Maribavir, has prompted us to expand the structure-activity relationships of the benzimidazole series, using as a central core the imidazo[4,5-b]pyridine scafflold. We have thus synthesized a number of novel amino substituted imidazopyridine nucleoside derivatives, which can be considered as 4-(or 7)-aza-d-isosters of Maribavir and have evaluated their potential antiviral activity. The target compounds were synthesized upon glycosylation of suitably substituted 2-aminoimidazopyridines, which were prepared in six steps starting from 2-amino-6-chloropyridine. Even if the new compounds possessed only a slight structural modification when compared to the original drug, they were not endowed with interesting antiviral activity. Even so, three derivatives showed promising cytotoxic potential.

PYRIDOPYRIMIDINONES AND THEIR USE AS NMDA RECEPTOR MODULATORS

-

Page/Page column 28, (2016/10/31)

The invention relates to pyridopyrimidinone compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein X, R, R2, R3, R4, R5 and R6 are as defined herein, as well as pharmaceutical compositions comprising such compounds, useful as NMDA receptor modulators in the treatment of neurological and psychiatric conditions.

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