1192874-50-2Relevant articles and documents
Synthesis of the NK1 receptor antagonist GW597599. Part 3: Development of a scalable route to a key chirally pure arylpiperazine urea, a happy end
Guercio, Giuseppe,Bacchi, Sergio,Perboni, Alcide,Leroi, Corinne,Tinazzi, Francesco,Bientinesi, Ilaria,Hourdin, Marie,Goodyear, Michael,Curti, Stefano,Provera, Stefano,Cimarosti, Zadeo
experimental part, p. 1100 - 1110 (2010/04/22)
GW597599 1 is a novel NK-1 antagonist currently under investigation for the treatment of central nervous system disorders and emesis. The initial chemical development synthetic route, derived from the one used by medicinal chemistry, involved several haza