1192875-04-9 Usage
General Description
(S)-tert-butyl 3-(3-aMino-5-(3-fluorophenyl)thiophene-2-carboxaMido)piperidine-1-carboxylate is a chemical compound with a complex structure. It contains a piperidine ring, a thiophene ring, and a carboxamido group, as well as a tert-butyl and a fluorophenyl substituent. (S)-tert-butyl 3-(3-aMino-5-(3-fluorophenyl)thiophene-2-carboxaMido)piperidine-1-carboxylate is involved in pharmaceutical research and development, with potential applications in the treatment of various diseases. Its precise pharmacological properties and potential therapeutic uses are currently being studied, and it is important for further research and testing to fully understand its potential benefits and risks.
Check Digit Verification of cas no
The CAS Registry Mumber 1192875-04-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,2,8,7 and 5 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1192875-04:
(9*1)+(8*1)+(7*9)+(6*2)+(5*8)+(4*7)+(3*5)+(2*0)+(1*4)=179
179 % 10 = 9
So 1192875-04-9 is a valid CAS Registry Number.
1192875-04-9Relevant articles and documents
An Improved Convergent Synthesis of AZD7762: A One-Pot Construction of a Highly Substituted Thiophene at the Multikilogram Scale
Ball, Matthew,Jones, Martin F.,Kenley, Fiona,Pittam, J. David
, p. 310 - 316 (2017/03/24)
A multikilogram synthesis of AZD7762 has been achieved using a highly convergent route employing two efficient telescoped sequences to generate the key intermediates. Aminothiophene 11 is formed in a four-step, one-pot addition-elimination-cyclization sequence from cinnamonitrile 9, constructing the trisubstituted thiophene ring with the desired API substitution pattern in place. Cinnamonitrile 9 is derived by elaboration of 3-fluoroacetophenone. Generation of the urea function, followed by deprotection, affords AZD7762 in 49% yield over 5 isolated stages from chiral piperidine 5, a 5-fold increase in yield versus the first generation route, reducing the starting material burden and eliminating the previous requirement for metal-mediated couplings and chromatography.
