119296-22-9Relevant academic research and scientific papers
Process for preparing optically active 1-(p-methoxybenzyl)-1,2,3,4,5,3,7,8-octahydroisoquinoline
-
, (2008/06/13)
Optically active 1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline having the formula (I) is prepared by asymmetric hydrogenation of the corresponding 3,4,5,6,7,8-hexahydro-compound or of the new 1-(p-methoxybenzyl)-3,4,5,6,7,8-hexahydroisoquinoline dihydrogenated phosphate in the present of chiral iridium-phosphine complexes. This product is an intermediate product in the synthesis of cough-relieving dextromethorphanne and analgesic levorphanol. STR1
Optically active 3,4-bis-(diphenylphosphino)-pyrrolidine, and rhodium complexes, containing it as chiral ligands
-
, (2008/06/13)
There are described new optically active 3,4-bis-(diphenylphosphino)-pyrrolidines of the formula STR1 wherein Ph is a phenyl group and R is hydrogen, an alkyl group, an arylalkyl group or an acyl group, rhodium complexes containing a compound of formula (I) as its chiral ligands, said rhodium complexes having the formula where (en)2 is two molecules of a monoolefin or one molecule of a diolefin, A is an optically active compound of formula (I) and X- is a tetrafluoroborate, hexafluorophosphate or a perchlorate ion, and use of the rhodium complexes as catalysts for the homogeneous asymmetric hydrogenation of unsubstituted or β-substituted α-acylamino-acrylic acids.
