1193-00-6

Basic information

• Product Name: 4-CHLOROPHENOL SODIUM SALT
• Synonyms: 4-CHLOROPHENOL SODIUM SALT;SODIUM 4-CHLOROPHENOLATE;chlorophenolsodiumsalt;Phenol,4-chloro-,sodiumsalt;Sodiump-chlorophenolate;4-CHLOROPHENOL SODIUM SALT 97+%;(4-Chlorophenoxy) sodium;Sodium 4-chlorophenoxide
• CAS NO: 1193-00-6
• Molecular Formula: C₆H₄ClO*Na
• Molecular Weight: 150.54
• EINECS: 214-762-9
• Mol File: 1193-00-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 220 °C at 760 mmHg
• Flash Point: 80.1 °C
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-CHLOROPHENOL SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROPHENOL SODIUM SALT(1193-00-6)
• EPA Substance Registry System: 4-CHLOROPHENOL SODIUM SALT(1193-00-6)

Safety Data

• Hazardous Substances Data: 1193-00-6(Hazardous Substances Data)

Usage

General Description

4-Chlorophenol sodium salt is a chemical compound that is commonly used as a disinfectant, fungicide, and bactericide. It is a white-to-light beige crystalline powder with a faint specific odor and is soluble in water. 4-CHLOROPHENOL SODIUM SALT is often utilized in industrial processes, such as the production of pharmaceuticals, pesticides, and dyes, as well as in the treatment of industrial wastewater. 4-Chlorophenol sodium salt has also been employed in the synthesis of various organic compounds and serves as a precursor in the preparation of other chemicals. However, it is important to handle this substance with caution, as it can cause skin and eye irritation upon contact and may have harmful effects if inhaled or ingested.

Upstream product

• 3233-55-4 4-Chlorophenyl sulfate 
• 695-96-5 2-bromo-4-chlorophenol 
• 1070428-60-2 p-chlorophenyl methylphosphonate sodium salt 
• 108-95-2 phenol 
• 80403-27-6 p-chlorophenyl hydrazinecarboxylate 
• 73823-11-7 N-phenyl-benzimidic acid-(4-chloro-phenyl ester) 
• 124-41-4 sodium methylate 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 555-89-5 bis(p-chlorophenoxy)methane 
• 95980-94-2 dimethyl-amidothiophosphoric acid O-ethyl ester-O'-(4-chloro-phenyl ester) 
• 96006-38-1 ethyl-amidothiophosphoric acid O-ethyl ester-O'-(4-chloro-phenyl ester) 
• 110144-78-0 diethylsulfamoyl-imidophosphoric acid tris-(4-chloro-phenyl ester) 
• 110147-01-8 diethylsulfamoyl-imidophosphoric acid tris-(2-chloro-phenyl ester) 
• 94211-73-1 benzoyl-amidophosphoric acid bis-(4-chloro-phenyl ester) 
• 5857-62-5 O,O-Diethyl O-p-chlorophenyl phosphorothioate 
• 13677-62-8 Thiophosphorsaeure-di-O-aethylester-O-<2-chlor-phenylester> 
• 80-33-1 chlorofensone 
• 299192-77-1 (N-phenyl)(benzyliden)(o-chlorophenoxy)imine 
• 5335-23-9 1-(p-chlorophenoxy)-propan-2-ol 
• 5335-22-8 1-(2-chloro-phenoxy)-propan-2-ol 
• 13997-70-1 1-allyloxy-4-chlorobenzene 
• 101414-37-3 6-p-chlorophenoxy-5-vinyl-4-thia-1-hexene 

Relevant articles and documents

Tyrosinase-like reactivity in a CuIII2(??-O) 2 species

A study was conducted to demonstrate a bis(??-oxo)dicopper(III) species that binds and ortho-hydroxylates phenolates for reactivity of tyrosinase. The study characterized a metastable species from the low-temperature reaction of sodium p-chloro-phenolate (p-Cl-C6H4ONa) with a bis(??-oxo)dicopper(III) species. The study found that the addition of 10 equivalents of the sodium salt of p-chlorophenol at -90?°C can cause bleaching of the spectral features. High performance liquid chromatography (HPLC) analysis showed that 4-chlorocatechol was formed in 76% yield. The study used UV/UVis monitoring for reaction in acetone to determine the initial features to the bis(??-oxo) species and found that these features disappear after phenolate addition. The study observed that the activation parameters for the monophenolase reaction catalyzed by tyrosinase.

Synthetic method for 2,5-dichloro-4-(4-chlorophenoxyl)-acetophenone

The invention discloses a synthetic method for 2,5-dichloro-4-(4-chlorophenoxyl)-acetophenone, which belongs to the field of chemical synthesis. The synthetic method comprises the following steps: adding sodium hydroxide into p-chlorophenol so as to obtain sodium p-chlorophenolate; then adding 1,3,5-trichlorobenzene, 1-methyl-2-pyrrolidone and a catalyst cuprous oxide so as to obtain a faint yellow viscous liquid; adding dichloroethane, an aluminum chloride catalyst and acetic anhydride into a bottle and slowing adding hydrochloric acid into the bottle in ice water with a temperature of 0 DEG C; and successively carrying out crystal precipitation, pumping filtration, cleaning, drying and recrystallization so as to obtain a 2,5-dichloro-4-(4-chlorophenoxyl)-acetophenone solid.

Mechanistic study of Protein Phosphatase-1 (PP1), a catalytically promiscuous enzyme

The reaction catalyzed by the protein phosphatase-1 (PP1) has been examined by linear free energy relationships and kinetic isotope effects. With the substrate 4-nitrophenyl phosphate (4NPP), the reaction exhibits a bell-shaped pH-rate profile for kcat/KM indicative of catalysis by both acidic and basic residues, with kinetic pKa values of 6.0 and 7.2. The enzymatic hydrolysis of a series of aryl monoester substrates yields a Bronsted βlg of -0.32, considerably less negative than that of the uncatalyzed hydrolysis of monoester dianions (-1.23). Kinetic isotope effects in the leaving group with the substrate 4NPP are 18(V/K)bridge = 1.0170 and 15(V/K) = 1.0010, which, compared against other enzymatic KIEs with and without general acid catalysis, are consistent with a loose transition state with partial neutralization of the leaving group. PP1 also efficiently catalyzes the hydrolysis of 4-nitrophenyl methylphosphonate (4NPMP). The enzymatic hydrolysis of a series of aryl methylphosphonate substrates yields a Bronsted βlg of -0.30, smaller than the alkaline hydrolysis (-0.69) and similar to the βlg measured for monoester substrates, indicative of similar transition states. The KIEs and the βlg data point to a transition state for the alkaline hydrolysis of 4NPMP that is similar to that of diesters with the same leaving group. For the enzymatic reaction of 4NPMP, the KIEs are indicative of a transition state that is somewhat looser than the alkaline hydrolysis reaction and similar to the PP1-catalyzed monoester reaction. The data cumulatively point to enzymatic transition states for aryl phosphate monoester and aryl methylphosphonate hydrolysis reactions that are much more similar to one another than the nonenzymatic hydrolysis reactions of the two substrates.