1193-30-2

Usage

Uses

Used in Pharmaceutical and Medicinal Chemistry:
6-Azaspiro[3.4]octan-5-one is used as a building block for the synthesis of various biologically active compounds, contributing to the development of new pharmaceuticals and medicines.
Used as a Precursor in Synthesis:
6-Azaspiro[3.4]octan-5-one serves as a precursor in the synthesis of other nitrogen-containing heterocycles, which are essential in creating complex organic molecules with potential applications in various industries.
Used in Flavor and Fragrance Production:
6-Azaspiro[3.4]octan-5-one is utilized in the production of certain synthetic flavors and fragrances, capitalizing on its distinctive chemical structure to create unique scents and tastes for various consumer products.

Upstream product

• 7646-66-4 N-benzoylaziridine 
• 14924-53-9 ethyl cyclobutylcarboxylate 

Relevant academic research and scientific papers

N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF

An N-(azaaryl)cyclolactam-1-carboxamide derivative having a structure of formula (I), a preparation method therefor, and a use thereof are disclosed in the application. Each substituent are defined in the specification and claims. The series of compounds of the application can be widely applied in the preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease or metastatic disease, particularly for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, primary tumor site metastasis or osseous metastasis cancer, and are expected to be developed into a new generation of CSF-1R inhibitor drugs.

HIGHLY ACTIVE CSF1R INHIBITOR COMPOUND

ABSTRACT The present invention relates to a CSF1R inhibitor, and in particular to a highly active CSF1R inhibitor compound having the structure of formula (I). Said compound of the present invention has high inhibitory activity on CSF1R.

Reaktionen mit Aziridinen, XXII. Einstufensynthese von Pyrrolidonen durch Amidoethylierung einfacher Ester mit N-Acylaziridinen

Sodium enolates of simple esters (2) react smoothly with N-acylaziridines (3) in THF forming 3-substituted 2-pyrrolidones 8.If the α-position of the ester carries more than one H-atom amidoethylated pyrrolidones can result.Whilst a simple butyrolactone behaves analogously amidoethylation of coumaranone furnished mono and bis amidoethyl derivatives of coumaranone besides a pyrrolidone. - In tert-butyl alcohol only extremly acidic esters like 1e and 1j could be amidoethylated.