1193-56-2 Usage
General Description
5-chloro-6-hydroxy-1H-pyrimidin-4-one, also known as 4-chloro-5-hydroxy-2-pyrimidinone or 5-chlorouracil, is a chemical compound with the molecular formula C4H3ClN2O2. It is a chlorinated derivative of uracil and is commonly used in the synthesis of pharmaceuticals, agrochemicals, and dyes. 5-chloro-6-hydroxy-1H-pyrimidin-4-one is known for its diverse biological activities, including anti-tumor, anti-viral, and anti-inflammatory properties, making it a valuable building block for medicinal chemistry research and drug development. 5-chloro-6-hydroxy-1H-pyrimidin-4-one is a widely studied chemical compound with potential applications in various fields due to its unique structural and pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1193-56-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,9 and 3 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1193-56:
(6*1)+(5*1)+(4*9)+(3*3)+(2*5)+(1*6)=72
72 % 10 = 2
So 1193-56-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H3ClN2O2/c5-2-3(8)6-1-7-4(2)9/h1H,(H2,6,7,8,9)
1193-56-2Relevant articles and documents
Synthesis method of 4,5,6-trichloropyrimidine
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Paragraph 0029, (2020/08/02)
The invention particularly relates to a synthesis method of 4,5,6-trichloropyrimidine. The method comprises the following steps: 1, dissolving diethyl malonate in dichloromethane, adding chlorosuccinimide at room temperature, and reacting to obtain an intermediate diethyl 2-chloromalonate; 2, dissolving sodium methoxide in methanol, cooling to room temperature, adding formamidine hydrochloride, stirring at room temperature after addition, adding the diethyl 2-chloromalonate in a dropwise manner, heating, carrying out a reflux reaction for 2-3 hours after addition, and purifying to obtain an intermediate 5-chloro-4,6-dihydroxypyrimidine; and 3, mixing the intermediate 5-chloro-4,6-dihydroxypyrimidine, phosphorus oxychloride and an organic alkali according to a weight ratio of 1:(5-10):(0.3-2), carrying out a chlorination reaction at 25-100 DEG C for 2-5 hours, cooling the mixture, carrying out reduced pressure concentration to remove redundant phosphorus oxychloride, adding water, quenching, extracting with an organic solvent, drying, and concentrating to obtain the product 4,5,6-trichloropyrimidine.
