1193-85-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyrimidinamine, 4-ethyl(9CI) is used as a building block for the synthesis of biologically active compounds. Its unique structure and functional groups make it a valuable component in the development of new pharmaceuticals.
Used in Antiviral and Antitumor Agent Development:
2-Pyrimidinamine, 4-ethyl(9CI) is used as a key intermediate in the development of antiviral and antitumor agents. Its chemical properties and potential interactions with biological targets make it a promising candidate for the creation of new therapeutic agents.
Used in Chemical Industry:
2-Pyrimidinamine, 4-ethyl(9CI) is used as a versatile chemical intermediate in various chemical synthesis processes. Its reactivity and compatibility with other chemical compounds make it a valuable asset in the development of new chemical products.

Upstream product

• 188707-99-5 2-chloro-4-ethylpyrimidine 
• 5734-67-8 2-amino-4-chloro-6-ethylpyrimidine 
• 127958-01-4 2-Amino-4-ethyl-pyrimidine-5-carboxylic acid 
• 5734-66-7 6-ethylisocytosine 
• 858447-26-4 4-ethyl-2-ethylmercapto-pyrimidine 
• 89193-23-7 2-[1-dimethylaminomethylidene]-3-oxo-pentanoic acid ethyl ester 
• 879025-57-7 6-ethyl-2-ethylmercapto-3H-pyrimidin-4-one 
• 859075-08-4 4-ethyl-2-ethylsulfanyl-6-chloro-pyrimidine 
• 127957-82-8 2-Amino-4-ethyl-pyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 2276-96-2 4-amino-N-(4-ethyl-pyrimidin-2-yl)-benzenesulfonamide 

Relevant academic research and scientific papers

PRMT5 INHIBITORS

The present invention provides a compound selected from: compounds A, B, C, D and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds disclosed herein, pharmaceutic

PRMT5 INHIBITORS

The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. VIII. Synthesis of Ethyl and Methyl 2,4-Disubstituted 5-Pyrimidinecarboxylates

Reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with N-C-N dinucleophiles such as guanidine, acetamidine or benzamidine afforded in high yields the relative esters of 4-substituted 2-amino-, 2-methyl- or 2-phenyl-5-pyrimidinecarboxylic acids, respectively.These esters were hydrolyzed to the corresponding carboxylic acids, which were converted by heating to 4-substituted 2-pyrimidinamines, 2-methyl or 2-phenylpyrimidines, respectively, generally in excellent yields.The 4-unsubstituted ethyl 2-amino-, 2-methyl- and 2-phenyl-5-pyrimidinecarboxylateswere obtained in moderate yields by reaction of the above dinucleophiles with ethyl 2,2-diformylacetate.These esters were hydrolyzed and the corresponding acids (with the exception of the 2-methyl derivative) were decarboxylated to give 2-pyrimidinamine and 2-phenylpyrimidine in satisfactory yields.