119305-43-0

Basic information

• Product Name: 1,3-diisothiocyanatobenzene
• Synonyms: benzene, 1,3-diisothiocyanato-
• CAS NO: 119305-43-0
• Molecular Formula: C₈H₄N₂S₂
• Molecular Weight: 192.2608
• Mol File: 119305-43-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 358.8°C at 760 mmHg
• Flash Point: 180.8°C
• Density: 1.2g/cm³
• Vapor Pressure: 5.12E-05mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: 1,3-diisothiocyanatobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-diisothiocyanatobenzene(119305-43-0)
• EPA Substance Registry System: 1,3-diisothiocyanatobenzene(119305-43-0)

Safety Data

• Hazardous Substances Data: 119305-43-0(Hazardous Substances Data)

Upstream product

• 463-71-8 thiophosgene 
• 541-69-5 m-phenylenediamine dihydrochloride 
• 75-15-0 carbon disulfide 
• 108-45-2 m-phenylenediamine 
• 67-66-3 chloroform 
• 123-61-5 1,3-Phenylene diisocyanate 
• 102368-13-8 1,1'-Thiocarbonyldi-2(1H)-pyridone 
• 19972-68-0 N,N'-(1,3-Phenylene)bis(methyldithiocarbamate) 

Downstream Products

• 20996-09-2 N,N'-m-phenylene-bis-thiocarbamic acid O,O'-diethyl ester 
• 111102-49-9 N,N'-(1,3-phenylene)bis(4-methoxybenzothioamide) 
• 16349-51-2 3,3,3',3'-tetraethyl-1,1'-m-phenylene-bis-thiourea 
• 2591-01-7 1,3-phenylenebisthiourea 
• 1620480-66-1 1,3-bis([N-[2,2']-bipyridin-5-yl-methyl]-thioureido)benzene 

Relevant articles and documents

NSCLC structure-activity relationship (sar) study of diisothiocyanates for antiproliferative activity on A549 Human non-small cell lung carcinoma (NSCLC)

Isothiocyanate functional group (-N=C=S) is widely accepted as an important moiety for anti-cancer effects of naturally occurring isothiocyanate compounds (ITCs). Herein, a series of diisothiocyanate (diITCs) derivatives were synthesized and evaluated in antiproliferative assays on A549 human non-small cell lung cancer and IMR90 human foetal lung cell lines for structure-activity relationship (SAR) and cancer cell selectivity studies. Results showed that aliphatic and benzylic diITCs were more cytotoxic to A549 cells than natural ITCs; benzyl isothiocyanate (BITC) and phenyl isothiocyanate (PITC), and a currently available anticancer drug; etoposide. Aromatic diITCs were not as active. Notably, most of the diITCs reported in this work were significantly more selective than etoposide to inhibit proliferation of the cancer cells (A549) over the normal cells (IMR90). This study demonstrated a guideline to modify chemical structures of diITCs for anti-NSCLC agents.

A sulfur key Lian Niao multifunctional synergistic antioxidant stabilizer preparation method

The invention relates to a preparation method of a multi-functional synergetic anti-oxidative stabilizer for sulfide bond linked urea. The preparation method comprises the following steps: (1) adding organic amine into CS2 and alkali to react; adding meth