119307-04-9

Basic information

• Product Name: 5-(4-(methylthio)phenyl)thiophene-2-carbaldehyde
• Synonyms: 5-(4-(methylthio)phenyl)thiophene-2-carbaldehyde
• CAS NO: 119307-04-9
• Molecular Weight: 234.343
• Mol File: 119307-04-9.mol

Chemical Properties

• CAS DataBase Reference: 5-(4-(methylthio)phenyl)thiophene-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-(methylthio)phenyl)thiophene-2-carbaldehyde(119307-04-9)
• EPA Substance Registry System: 5-(4-(methylthio)phenyl)thiophene-2-carbaldehyde(119307-04-9)

Safety Data

• Hazardous Substances Data: 119307-04-9(Hazardous Substances Data)

Upstream product

• 98546-51-1 (4-thiomethoxyphenyl)boronic acid 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 1003-09-4 2-bromothiophene 
• 18620-04-7 4-thioanisolemagnesium bromide 

Downstream Products

• 1313397-32-8 5-((5-(4-(methylthio)phenyl)thiophen-2-yl)methylene)-2-thioxoimidazolidin-4-one 

Relevant articles and documents

Role of pyridine nitrogen in palladium-catalyzed imine hydrolysis: A Case Study of (E)-1-(3-bromothiophen-2-yl)-N-(4-methylpyridin-2-yl)methanimine

In the present study, 4-methylpyridin-2-amine was reacted with 3-bromothiophene-2-carbaldehyde and the Schiff base (E)-1-(3-bromothiophen-2-yl)-N-(4-methylpyridin-2-yl) methanimine was obtained in a 79% yield. Coupling of the Schiff base with aryl/het-aryl boronic acids under Suzuki coupling reaction conditions, using Pd(PPh3)4 as catalyst, yielded products with the hydrolysis of the imine linkages (5a–5k, 6a–6h) in good to moderate yields. To gain mechanistic insight into the transition metal-catalyzed hydrolysis of the compounds, density functional theory (DFT) calculations were performed. The theoretical calculations strongly supported the experiment and provided an insight into the transition metal-catalyzed hydrolysis of imines.

COMPOUNDS, PREPARATIONS AND USES THEREOF

The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as agents or drugs for inhibiting perforin activity and for treating a subject at risk of or susc

2-(2,2-dihaloethenyl)-5-arylthiophene pesticides

Thiophene derivatives of the following formula are effective as acaricides: STR1 wherein RA is selected from -hydrogen, -halogen, -lower alkyl, hydroxy, -lower alkoxy, -lower alkylthio, -lower alkoxyalkoxy, -lower alkoxycarbonyl, -aryloxycarbonyl, -lower alkoxycarbonyloxy, -lower alkylsulfonyl, -lower alkylsulfonyloxy, -arylsulfonyloxy, and -lower alkyl phosphonyloxy; RB is -hydrogen, or RA and RB together are --C4 H4 --bridging 2'-3' or 3'-4'; R3 and R4 are selected from -hydrogen, -lower alkyl, and -aryl; X is -halogen; and Y is selected from -hydrogen and -halogen.