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1193314-23-6

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  • Spiro[3H-indole-3,1'-[1H]pyrido[3,4-b]indol]-2(1H)-one, 5,7'-dichloro-6'-fluoro-2',3',4',9'-tetrahydro-3'-methyl-, (1'R,3'S)-

    Cas No: 1193314-23-6

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1193314-23-6 Usage

General Description

NITD 609 is a chemical compound that has shown promising antimalarial activity. It belongs to the imidazolopiperazine class of compounds and has been found to be effective against both drug-sensitive and drug-resistant strains of the malaria parasite. NITD 609 works by targeting the dihydroorotate dehydrogenase (DHODH) enzyme, a crucial enzyme involved in the de novo pyrimidine biosynthesis pathway of the parasite. This unique mode of action makes NITD 609 a potential candidate for the development of new antimalarial drugs. Additionally, it has shown good oral bioavailability, low toxicity, and favorable pharmacokinetic properties, making it a promising lead compound for further development as a new antimalarial therapy.

Check Digit Verification of cas no

The CAS Registry Mumber 1193314-23-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,3,3,1 and 4 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1193314-23:
(9*1)+(8*1)+(7*9)+(6*3)+(5*3)+(4*1)+(3*4)+(2*2)+(1*3)=136
136 % 10 = 6
So 1193314-23-6 is a valid CAS Registry Number.

1193314-23-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methylspiro[1H-indole-3,1'-2,3,4,9-tetrahydropyrido[3,4-b]indole]-2-one

1.2 Other means of identification

Product number -
Other names NITD 609

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1193314-23-6 SDS

1193314-23-6Downstream Products

1193314-23-6Relevant articles and documents

Stereoselective Total Synthesis of KAE609 via Direct Catalytic Asymmetric Alkynylation to Ketimine

Takada, Hisashi,Kumagai, Naoya,Shibasaki, Masakatsu

, p. 4762 - 4765 (2015)

A direct catalytic asymmetric alkynylation protocol is applied to provide the requisite enantioenriched propargylic α-tertiary amine, allowing for the stereoselective total synthesis of KAE609 (formerly NITD609 or cipargamin).

Tertiary amine compound, bisphosphine ligand, and intermediate and preparation method of tertiary amine compound

-

, (2019/11/20)

The invention discloses a tertiary amine compound, a bisphosphine ligand, and an intermediate and a preparation method of the tertiary amine compound, and provides a tertiary amine compound preparation method, which comprises: under the protection of a ga

A asymmetric catalytic synthesis volute four hydrogens[...] compounds

-

Paragraph 0080; 0081; 0084, (2017/03/14)

The invention discloses a method for asymmetric catalytic synthesis of a spirocyclic tetrahydrocarbazoline compound, comprising the steps: by taking 3-alkenyl indole and isatin derived ketimine as raw materials, a complex formed by chiral amine oxide and nickel trifluoromethane sulfonate as a catalyst and dichloromethane as a solvent, performing reaction on the raw materials at (-30) DEG C to (-10) DEG C at the normal pressure for 96-192h; then adding 6.0M HCl(solution) and performing reaction at 30 DEG C for 4-48h to obtain the chiral spirocyclic tetrahydro carbazoline compound, wherein the yield of the chiral spirocyclic tetrahydro carbazoline compound can reach up to 95%, and the enantioselectivity can reach up to 99%. According to the method provided by the invention, the catalytic reaction conforms with the green chemistry atom economy and has a good prospect in industrial application, thereby providing a new path for asymmetric synthesis of compounds with high anti-malarial activity (NITD609).

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