1193367-05-3Relevant articles and documents
Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA)
West, Christopher W.,Adler, Marc,Arnaiz, Danny,Chen, Deborah,Chu, Kieu,Gualtieri, Giovanna,Ho, Elena,Huwe, Christoph,Light, David,Phillips, Gary,Pulk, Rebecca,Sukovich, Drew,Whitlow, Marc,Yuan, Shendong,Bryant, Judi
, p. 5712 - 5715 (2009)
In this Letter we report the synthesis and evaluation of a series of non-amidine inhibitors of Urokinase Plasminogen Activator (uPA). Starting from compound 1, a significant change provided compounds in which the amidine, binding in the S1 pocket, was rep