1193383-09-3

Basic information

• Product Name: 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid
• Synonyms: 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid;JNJ-42041935;1-[6-Chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]-1H-pyrazole-4-carboxylic acid
• CAS NO: 1193383-09-3
• Molecular Formula: C12H6ClF3N4O3
• Molecular Weight: 346.6492496
• Mol File: 1193383-09-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 555.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.82±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.52±0.10(Predicted)
• CAS DataBase Reference: 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid(1193383-09-3)
• EPA Substance Registry System: 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid(1193383-09-3)

Safety Data

• Hazardous Substances Data: 1193383-09-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1193383-09-3 differently. You can refer to the following data:
1. Hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) enzymes act as central gatekeepers of posttranscriptional and transcriptional adaptation to hypoxia, oxidative stress, and excitotoxicity. Their catalytic activity is dependent on iron, 2-oxoglutarate (2-OG), and oxygen, and leads to the stabilization of a host of proteins, including the hypoxia-inducible transcription factors in response to oxygen availability. Inhibitors of PHD have been used to mimic a hypoxic response in order to study a range of oxygen-deprivation-related disorders, including anemia, ulcerative colitis, myocardial ischemia, stroke, and metabolic disorders. JNJ-42041935 is a selective, 2-OG competitive, and reversible inhibitor of PHD enzymes (pKis = 7.91, 7.29, and 7.65 for PHD1, 2, and 3, respectively). It is >100-fold selective for PHD compared to the related FIH (factor-inhibiting HIF) and a panel of various other enzymes. In an inflammation-induced anemia model in rats, 100 μM/kg/day JNJ-42041935 significantly increased the number of circulating reticulocytes and red blood cells, increased blood hemoglobin and hematocrit, and restored mean corpuscular volume and mean cell hemoglobin of red bloods cells.[Cayman Chemical]
2. JNJ 42041935 is a selective hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) enzyme inhibitor. It can potentially be used for the treatment of inflammation-induced anemia.

Upstream product

• 1193384-77-8 1-(6-chloro-1-dimethylsulfamoyl-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 1193384-76-7 2,6-dichloro-5-trifluoromethoxy-benzoimidazole-1 sulfonic acid dimethylamide 
• 1193384-74-5 5-chloro-6-trifluoromethoxy-1,3-dihydro-benzoimidazol-2-one 
• 1193384-75-6 2,6-dichloro-5-trifluoromethoxy-1H-benzoimidazole 
• 156425-08-0 4-chloro-5-(trifluoromethoxy)benzene-1,2-diamine 
• 914637-23-3 5-chloro-2-nitro-4-trifluoromethoxy-phenylamine 

Relevant articles and documents

BENZOIMIDAZOLES AS PROLYL HYDROXYLASE INHIBITORS

The present invention is directed to benzoimidazole compounds of the formula (1) and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and met