1193388-07-6

Basic information

• Product Name: tert-Butyl (2-aMinocyclopentyl)carbaMate
• Synonyms: tert-Butyl (2-aMinocyclopentyl)carbaMate
• CAS NO: 1193388-07-6
• Molecular Formula: C10H20N2O2
• Molecular Weight: 200.278
• Mol File: 1193388-07-6.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 304.2±31.0 °C(Predicted)
• Appearance: /
• Density: 1.04±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.25±0.40(Predicted)
• CAS DataBase Reference: tert-Butyl (2-aMinocyclopentyl)carbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl (2-aMinocyclopentyl)carbaMate(1193388-07-6)
• EPA Substance Registry System: tert-Butyl (2-aMinocyclopentyl)carbaMate(1193388-07-6)

Safety Data

• Hazardous Substances Data: 1193388-07-6(Hazardous Substances Data)

Usage

Uses

tert-Butyl (2-aminocyclopentyl)carbamate (cas# 1193388-07-6) is used as a reactant in the synthetic preparation of carboxamides as inhibitors of IRAK4 activity.

Upstream product

• 928776-87-8 tert-butyl (1S,2S)-N-[2-(N'-allyl-N'-benzylamino)cyclopentyl]carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 815645-30-8 tert-butyl (1R,2R)-2-(benzyloxycarbonylamino)cyclopentylcarbamate 
• 1193388-07-6 tert-butyl rac-trans-(2-aminocyclopentyl)carbamate 
• 477873-22-6 (1R,2R)-trans-1,2-cyclopentanediamine dihydrochloride 
• 285-67-6 Cyclopentene oxide 
• 77924-51-7 trans-2-(diallylamino)cyclopentanol 

Downstream Products

• 1517-69-7 (R)-1-phenylethanol 
• 1205616-17-6 tert-butyl (1S,2R)-[(2-acetylamino)cyclopentyl]carbamate 
• 721395-15-9 (1S,2R)-2-(N-t-butyloxycarbonylamino)-1-aminocyclopentane 
• 445479-01-6 (1R,2S)-2-tert-Butoxycarbonylaminocyclopentylamine 
• 1205616-06-3 tert-butyl (1R,2R)-N-[2-(acetylamino)cyclopentyl]carbamate 
• 586961-34-4 (-)-(1S,2S)-N-mono(tert-butoxycarbonyl) cyclopentane-1,2-diamine 
• 1616435-24-5 4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(4aS,7aS)-3-oxooctahydro-1H-cyclopenta[b]pyrazin-1-yl]-3H-imidazo[4,5-c]pyridine-6-carbonitrile 
• 1616435-25-6 4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(4aS,7aS)-4-methyl-3-oxooctahydro-1H-cyclopenta[b]pyrazin-1-yl]-3H-imidazo[4,5-c]pyridine-6-carbonitrile 

Relevant articles and documents

An improved chemoenzymatic synthesis of both enantiomers of trans-cyclopentane-1,2-diamine

An improved chemoenzymatic protocol for the synthesis of both enantiomers of trans-cyclopentane-1,2-diamine is described. The key part of the strategy relies on the synthesis and subsequent enzymatic resolution of its racemic precursor trans-N,N-diallylcy

CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

A preparing high optical purity of the trans -1,2-cyclic diamine method

The invention discloses a method for preparing high-optical-purity trans-1,2-cyclodiamine and provides a method for preparing trans-1,2-diamine despinner by carrying out trans-ring-opening reaction on a p-tolylsulfonyl aza-bicyclic compound through chiral phenethylamine under the action of lithium perchlorate. The method comprises the following steps: reacting a trans-1,2-diamine despinner compound with acid to generate trans-1,2-diamine despinner compound acid salt; performing resolution through a step-by-step re-crystallization process to obtain a high-optical-purity (R,R)-1,2-diamine (Xb) compound and (S,S)-1,2-diamine compound monomer acid salt respectively; hydrogenating a trans-1,2-diamine (Xb) compound monomer under the action of a palladium catalyst to remove benzyl so as to obtain high-optical-purity trans-1,2-p-tolylsulfonyl cyclopentanediamine; protecting the amino of a high-optical-purity trans-1,2-cyclodiamine (Xc) monomer through an amino protecting agent; removing p-tolylsulfonyl at a low temperature through lithium naphthalene to obtain a high-optical-purity trans-t-butyloxycarboryl-1,2-cyclodiamine (Xd) compound monomer. The method is high in yield, low in cost and suitable for industrial production.