1193446-73-9Relevant academic research and scientific papers
A facile and efficient synthesis of 4-hydroxy-2,6-c/s-tetrahydropyrans via tandem cross-metathesis/thermal sn2′ reaction: protecting-group-free synthesis of (±)-diospongin A
Lee, Kiyoun,Kim, Hyoungsu,Hong, Jiyong
supporting information; experimental part, p. 5202 - 5205 (2010/02/28)
The tandem cross-metathesis/thermal SN2' reaction was explored for the facile and efficient synthesis of 4-hydroxy-2,6-cis-tetrahydropyrans. The mildness of the thermal conditions allowed for the synthesis of 4-hydroxy-2,6-cis-tetrahydropyrans from base-sensitive substrates without the use of protecting groups. The tandem reaction enabled a protecting-group-free synthesis of (±)-diospongin A.
