119347-14-7

Basic information

• Product Name: 2-Deacetoxytaxinine J
• Synonyms: 2-Deacetoxytaxinine J;2alpha-Deacetoxytaxinine J
• CAS NO: 119347-14-7
• Molecular Formula: C₃₇H₄₆O₁₀
• Molecular Weight: 650.75514
• Mol File: 119347-14-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 169-171℃
• Appearance: /
• CAS DataBase Reference: 2-Deacetoxytaxinine J(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Deacetoxytaxinine J(119347-14-7)
• EPA Substance Registry System: 2-Deacetoxytaxinine J(119347-14-7)

Safety Data

• Hazardous Substances Data: 119347-14-7(Hazardous Substances Data)

Usage

General Description

2-Deacetoxytaxinine J is a chemical compound derived from the taxinine family, which is known for its potential anti-tumor and anti-cancer properties. This chemical has been found to inhibit the growth and proliferation of cancer cells by disrupting microtubule assembly and function. Studies have shown that 2-Deacetoxytaxinine J has the ability to induce cell cycle arrest and apoptosis in various cancer cell lines, making it a promising candidate for the development of new anti-cancer drugs. Its mechanism of action suggests that it may be effective in the treatment of a variety of cancer types, making it an important compound for further research and potential therapeutic applications.

Upstream product

• 119777-80-9 2-deacetoxy-5-(3'-dimethylamino-3'-phenylpropionoxy)taxinine J 

Downstream Products

• 87193-98-4 acetic acid 7,10,13-triacetoxy-5-hydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0(3,8)]pentadec-11-en-9-ylester 
• 1221188-68-6 C₃₅H₄₂O₈ 
• 1189177-68-1 3-phenyl-propionic acid 7,9,10,13-tetraacetoxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0(3,8)]pentadec-11-en-5-ylester 
• 177595-05-0 Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4-hydroxy-5-methanesulfonyloxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.0^3,8]pentadec-11-en-9-yl ester 
• 177595-04-9 Acetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4,5-dihydroxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.0^3,8]pentadec-11-en-9-yl ester 
• 237428-99-8 C₇₁H₁₀₄O₂₀Si₂ 
• 934686-97-2 2-(2,4-dimethoxy-phenyl)-4-isobutyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-[7,9,10-triacetoxy-8,12,15,15-tetramethyl-4-methylene-5-(3-phenyl-acryloyloxy)-tricyclo[9.3.1.0^3,8]pentadec-11-en-13-yl] ester 
• 934686-96-1 2-(2,4-dimethoxy-phenyl)-4-isobutyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-(7,9,10-triacetoxy-5-hydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0^3,8]pentadec-11-en-13-yl) ester 

Relevant articles and documents

Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J

A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 μM when tested in combination

Synthesis of azetidine-type taxanes

Starting from the alkaloid 2'-deacetoxyaustrospicatine (2) azetidine isosteres of the oxetane-type laxane 1-deoxy-2-debenzoyloxy-4-deacetylbaccatin VI were synthesized.

PLANTES DE NOUVELLE-CALEDONIE. 114. TAXANES ISOLES DES FEUILLES D'AUSTROTAXUS SPICATA COMPTON (TAXACEES)

Seventeen compounds have been isolated from the leaves of Austrotaxus spicata: anemonine, usually extracted only from Renonculaceae, is the main product; the other have a taxane skeleton.Fourteen are alkaloidal and new; among these, twelve are described h