119347-14-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Deacetoxytaxinine J is used as a potential anti-cancer agent for its ability to inhibit the growth and proliferation of cancer cells. It is particularly effective in inducing cell cycle arrest and apoptosis, making it a promising candidate for the development of new anti-cancer drugs.
2-Deacetoxytaxinine J is used as a research compound for further investigation into its mechanism of action and potential therapeutic applications in the treatment of various cancer types. Its effectiveness in disrupting microtubule assembly and function suggests that it may be a valuable tool in the development of targeted cancer therapies.

Upstream product

• 119777-80-9 2-deacetoxy-5-(3'-dimethylamino-3'-phenylpropionoxy)taxinine J 

Downstream Products

• 87193-98-4 acetic acid 7,10,13-triacetoxy-5-hydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0(3,8)]pentadec-11-en-9-ylester 
• 934686-96-1 2-(2,4-dimethoxy-phenyl)-4-isobutyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-(7,9,10-triacetoxy-5-hydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0^3,8]pentadec-11-en-13-yl) ester 
• 934686-97-2 2-(2,4-dimethoxy-phenyl)-4-isobutyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-[7,9,10-triacetoxy-8,12,15,15-tetramethyl-4-methylene-5-(3-phenyl-acryloyloxy)-tricyclo[9.3.1.0^3,8]pentadec-11-en-13-yl] ester 
• 237428-99-8 C₇₁H₁₀₄O₂₀Si₂ 
• 1221188-68-6 C₃₅H₄₂O₈ 
• 1189177-68-1 3-phenyl-propionic acid 7,9,10,13-tetraacetoxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0(3,8)]pentadec-11-en-5-ylester 

Relevant academic research and scientific papers

Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J

A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 μM when tested in combination

Synthesis of paclitaxel (docetaxel) / 2-deacetoxytaxinine J dimers

Starting from taxanes available in multigram amounts from widespread ornamental yews (10-deacetylbaccatin III (4) and 2'-deacetoxyaustrospicatine (5)), two dimeric taxoids (3a, 3b) with potential dual target specificity (β-tubulin and P-gp) were synthesised. Both compounds lacked significant cytotoxicity, though 3b retained a strong activity in the tubulin depolimerisation assay.

Studies on the Himalayan yew Taxus wallichiana: Part III - First report on isolation of a basic taxane

The basic taxane 2′-deacetoxyaustrospicatine (1) has been isolated from the stem bark and needles of Taxus wallichiana, and converted into 2-deacetoxytaxinine J (2) through chemical reactions. This is the first report on the isolation of a basic taxane from the Himalayan yew.

Synthesis of azetidine-type taxanes

Starting from the alkaloid 2'-deacetoxyaustrospicatine (2) azetidine isosteres of the oxetane-type laxane 1-deoxy-2-debenzoyloxy-4-deacetylbaccatin VI were synthesized.

PLANTES DE NOUVELLE-CALEDONIE. 114. TAXANES ISOLES DES FEUILLES D'AUSTROTAXUS SPICATA COMPTON (TAXACEES)

Seventeen compounds have been isolated from the leaves of Austrotaxus spicata: anemonine, usually extracted only from Renonculaceae, is the main product; the other have a taxane skeleton.Fourteen are alkaloidal and new; among these, twelve are described h