1193512-41-2Relevant academic research and scientific papers
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: Synthesis and optimization studies of benzothiazine-substituted tetramic acids
de Vicente, Javier,Hendricks, Robert T.,Smith, David B.,Fell, Jay B.,Fischer, John,Spencer, Stacey R.,Stengel, Peter J.,Mohr, Peter,Robinson, John E.,Blake, James F.,Hilgenkamp, Ramona K.,Yee, Calvin,Zhao, Junping,Elworthy, Todd R.,Tracy, Jahari,Chin, Elbert,Li, Jim,Lui, Al,Wang, Beihan,Oshiro, Connie,Harris, Seth F.,Ghate, Manjiri,Leveque, Vincent J.P.,Najera, Isabel,Pogam, Sophie Le,Rajyaguru, Sonal,Ao-Ieong, Gloria,Alexandrova, Ludmila,Fitch, Bill,Brandl, Michael,Masjedizadeh, Mohammad,Wu, Shao-yong,Keczer, Steve de,Voronin, Tatyana
scheme or table, p. 5648 - 5651 (2010/04/05)
Benzothiazine-substituted tetramic acids were discovered as highly potent non-nucleoside inhibitors of HCV NS5B polymerase. X-ray crystallography studies confirmed the binding mode of these inhibitors with HCV NS5B polymerase. Rational optimization of tim
