119353-30-9Relevant academic research and scientific papers
Synthesis of Secondary Allylic Amines
Kimpe, Norbert de,Stanoeva, Elena,Verhe, Roland,Schamp, Niceas
, p. 587 - 592 (2007/10/02)
Secondary allylic amines were synthesized from aldehydes and primary amines via successive conversion into aldimines, α-haloaldimines and α,β-unsaturated aldimines, the latter being selectively reduced by sodium borohydride at the imino function.This method allowed the synthesis of secondary allylic amines with high preponderance of the E-stereochemistry.A comparison was made with an alternative method involving the generation of α,β-unsaturated aldimines from α,β-unsaturated aldehydes and primary amines, and subsequent borohydride reduction.
