1193686-64-4

Basic information

• Product Name: C₃₆H₃₇ClF₃NO₃
• CAS NO: 1193686-64-4
• Molecular Weight: 624.143
• Mol File: 1193686-64-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₆H₃₇ClF₃NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₃₇ClF₃NO₃(1193686-64-4)
• EPA Substance Registry System: C₃₆H₃₇ClF₃NO₃(1193686-64-4)

Safety Data

• Hazardous Substances Data: 1193686-64-4(Hazardous Substances Data)

Upstream product

• 405911-26-4 methyl 2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}-(2,2-diphenylethyl)-amino)-propoxy]phenyl}acetate 
• 74-88-4 methyl iodide 

Downstream Products

• 610318-95-1 C₃₅H₃₅ClF₃NO₃ 

Relevant articles and documents

The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages

The liver X receptors (LXR) play a key role in cholesterol homeostasis and lipid metabolism. SAR studies around tertiary-amine lead molecule 2, an LXR full agonist, revealed that steric and conformational changes to the acetic acid and propanolamine groups produce dramatic effects on agonist efficacy and potency. The new analogs possess good functional activity, demonstrating the ability to upregulate LXR target genes, as well as promote cholesterol efflux in macrophages.