119372-63-3Relevant academic research and scientific papers
Difluoromethyleneketone retroamide, a versatile concept of inactivation of proteolytic enzymes
Schirlin,Baltzer,Altenburger,Tarnus,Remy
, p. 305 - 318 (2007/10/02)
The synthesis of difluoromethyleneketone retroamides is described. Several examples of application to aspartyl or seryl proteases illustrate the versatility of this inactivation concept. Copyright
A CONVENIENT SYNTHESIS OF &α',&β-DIAMINO- &α,&α-DIFLUOROKETONES, NEW DIPEPTIDE ISOSTERES
Schirlin, D.,Baltzer, S.,Altenburger, J. M.
, p. 3687 - 3690 (2007/10/02)
A convenient and versatile synthesis of α',β-diamino-α,α-difluoroketones is described.These compounds represent a new class of true dipeptide isosteres useful for the design of serine protease inhibitors.
