1193752-37-2Relevant academic research and scientific papers
Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3′,5′-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist
Venkatraman, Shankar,Lebsack, Alec D.,Alves, Kenneth,Gardner, Michael F.,James, Joyce,Lingham, Russell B.,Maniar, Salony,Mumford, Richard A.,Si, Qian,Stock, Nicholas,Treonze, Kelly M.,Wang, Bowei,Zunic, Jasmine,Munoz, Benito
scheme or table, p. 5803 - 5806 (2010/04/25)
A series of prolyl-N-isonicotinoyl-(L)-4-aminophenylalanine derivatives substituted at the proline 4-position with cyclic amines was evaluated as VLA-4 antagonists. The ring size and presence or absence of fluorine affected potency and receptor occupancy.
