1194-16-7

Basic information

• Product Name: 2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE
• Synonyms: AKOS NCG-0015;Tetrahydro-2,2-dimethyl-4H-pyran-4-one, 95%;2,2-dimethyltetrahydro-4H-pyran-4-one;Ec-000.1609;2,2-Dimethyltetrahydropyran-4-one ,95%;2,2-diMethyldihydro-2H-pyran-4(3H)-one;2,2-DiMethyltetrahydro-4-pyrone;4H-Pyran-4-one, tetrahydro-2,2-diMethyl-
• CAS NO: 1194-16-7
• Molecular Formula: C₇H₁₂O₂
• Molecular Weight: 128.16898
• Mol File: 1194-16-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 60-64°C/8mm
• Flash Point: 60-64°C/8mm
• Appearance: /
• Density: 0.968 g/cm³
• Vapor Pressure: 0.995mmHg at 25°C
• Refractive Index: 1.428
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE(1194-16-7)
• EPA Substance Registry System: 2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE(1194-16-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1194-16-7(Hazardous Substances Data)

Usage

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

InChI:InChI=1/C7H12O2/c1-7(2)5-6(8)3-4-9-7/h3-5H2,1-2H3

Upstream product

• 102548-00-5 1-hydroxy-5-methyl-hex-4-en-3-one 
• 7664-93-9 sulfuric acid 
• 856350-52-2 5-chloro-5-methyl-hex-1-en-3-one 
• 18927-48-5 2,2-dimethyl-2,3-dihydropyran-4-one 
• 135049-78-4 4-[5-fluoro-3-(naphth-2-yloxy)phenyl]-4-hydroxy-2,2-dimethyltetrahydropyran 
• 50-00-0 formaldehyd 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 41854-09-5 1,5-dimethoxy-5-methyl-hexan-3-one 
• 13221-56-2 2-methyl-6-methoxy-2-hexen-4-one 
• 109752-89-8 4-hydroxymethyl-2,2-dimethyltetrahydropyran-4-ol 
• 102880-85-3 1-acetoxy-5-methyl-hex-4-en-3-one 
• 859972-13-7 1,5-dichloro-5-methyl-hexan-3-one 
• 690-94-8 dimethyl(vinylethynyl)carbinol 
• 13058-38-3 5-methyl-hexa-1,4-dien-3-one 

Relevant articles and documents

NEW PYRIDO[3',2':4,5]FURO[3,2-d]PYRIMIDINE DERIVATIVES

The present invention provides a pyridofuropyrimidine derivative of formula (I): wherein G1 represents a group selected from -CR6R7- and -O- wherein R6 and R7 independently represent hydrogen atoms or C1-4 alkyl groups; R1 and R2 are independently selected from hydrogen atoms and C1-4 alkyl groups; R3 represents a group selected from C1-4 alkyl, C1-4 alkoxy, amino, hydroxy, mono- C1-4 alkylamino, di- C1-4 alkylamino, C3-8 cycloalkylamino, aryl, heteroaryl and saturated N-containing heterocyclyl groups which are bound to the pyridine ring through their nitrogen atom, all of them being optionally substituted by one or more substituents selected from the group consisting of halogen atoms and hydroxy, C1-4 alkyl, C1-4 alkoxy- C1-4 alkyl, aryl-C1-4 4alkyl, -O(CO)O R8, C1-4 alkoxy, -(CO)NR8R9, -CN, -CF3, -NR8R9, -SR8 and -SO2NH2 groups wherein R8 and R9 each independently represent a hydrogen atom or a C1-4 alkyl group; R4 and R5 are independently selected from the group consisting of hydrogen atoms, C1-4 alkyl groups, hydroxyl- C1-4 alkyl groups and groups of formula (II): wherein p and q are integers selected from 0, 1 , 2 and 3; A is either a direct bond or a group selected from -CONR14-, -NR14CO-, -0-, -COO-, -OCO-, -S-, -SO- and -SO2-, wherein each R10, R11, R12, R13 and R14 independently represents a hydrogen atom or a C1-4 alkyl group and G2 is a group selected from aryl, heteroaryl or heterocyclyl groups; wherein the group G2 is optionally substituted by one or more substituents selected from group consisting of halogen atoms and C1-4 alkyl, hydroxy, oxo, C1-4 alkoxy- C1-4 alkyl, aryl- C1-4 alkyl, -(CO)OR16, C1-4 alkoxy, -(CO)NR16R17, -CN, -CF3, -NR16R17, -SR16 and -SO2NH2 groups; wherein R16 and R17 each independently represent a hydrogen atom or a C1-4 alkyl group and the pharmaceutically acceptable salts and N-oxides thereof.

4(SPIROPIPERIDINYL)METHYL SUBSTITUTED PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

3-Substituted pyrrolidines having a spiropiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.

Synthesis and biological activity of a novel class of pyridazine analogues as non-competitive reversible inhibitors of protein tyrosine phosphatase 1B (PTP1B).

A series of novel pyridazine analogues were prepared and the structure-activity relationship of their behavior as inhibitors of PTP1B was evaluated. Most of the analogues had potencies in the low micromolar range. The in vitro kinetics of this compound series demonstrated that they were reversible non-competitive binders. This indicates that there may exist another site in the enzyme through which enzyme activity can be inhibited, which is not a recognized interaction domain. Some of the analogues exhibited high selectivity for other PTPases, for example, compound 12 mp showed 20-fold selectivity for PTP1B (IC50=5.6 microM) versus both TCPTP and LAR (>100 microM, respectively). In contrast to many tyrosine phosphatase mimetic inhibitors, this compound class lacks negative charge and thus showed high permeability across cell membranes. Selective analogues in the series were analyzed in an in vitro cellular assay, which showed increased insulin-stimulated insulin receptor phosphorylation.