1194019-76-5

Basic information

• Product Name: 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid
• Synonyms: 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid
• CAS NO: 1194019-76-5
• Molecular Weight: 256.236
• Mol File: 1194019-76-5.mol

Chemical Properties

• CAS DataBase Reference: 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid(1194019-76-5)
• EPA Substance Registry System: 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid(1194019-76-5)

Safety Data

• Hazardous Substances Data: 1194019-76-5(Hazardous Substances Data)

Upstream product

• 677306-38-6 1H-indazole-4-carboxylic acid 
• 352-34-1 4-fluoro-1-iodobenzene 
• 192945-49-6 1H-indazole-4-carboxylic acid methyl ester 
• 1194019-74-3 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid methyl ester 

Downstream Products

• 1194017-77-0 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (6-bromo-pyridin-3-ylmethyl)-amide 
• 1194018-01-3 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (1-naphthalen-1-yl-ethyl)-amide 
• 1194017-72-5 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 4-methylsulfamoyl-benzylamide 
• 1194019-61-8 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid [(S)-1-(6-bromo-pyridin-3-yl)-propyl]-amide 
• 1194019-84-5 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid chloride 
• 1194019-95-8 C₂₁H₁₇FN₄O₂ 
• 1194019-15-2 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (6-ethynyl-pyridin-3-ylmethyl)-amide 
• 1194018-62-6 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (6-methanesulfonyl-pyridin-3-ylmethyl)-amide 
• 1194018-57-9 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (6-carbamoyl-pyridin-3-ylmethyl)-amide 
• 1194019-97-0 C₂₂H₁₉FN₄O₄S 
• 1194019-17-4 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (6-methanesulfonylmethyl-pyridin-3-ylmethyl)-amide 
• 1194018-56-8 5-({[1-(4-fluoro-phenyl)-1H-indazole-4-carbonyl]-amino}-methyl)-pyridine-2-carboxylic acid ethyl ester 
• 1194019-93-6 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (6-trimethylsilanylethynyl-pyridin-3-ylmethyl)-amide 

Relevant articles and documents

Identification of novel azaindazole CCR1 antagonist clinical candidates

Exploring various cyclization strategies, using a submicromolar pyrazole HTS screening hit 6 as a starting point, a novel indazole based CCR1 antagonist core was discovered. This report presents the design and SAR of CCR1 indazole and azaindazole antagonists leading to the identification of three development compounds, including 19e that was advanced to early clinical trials.

INDAZOLE AND PYRAZOLOPYRIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS

Diclosed are CCRl receptor antagonists of the formula (I), wherein X is nitrogen or, C-R2; Ar1 is carbocycle, heteroaryl or heterocyclyl each optionally substituted by one to three Ra; Ar2 is carbocycle, heteroaryl or heterocyclyl, each optionally substituted by one to three Rb; Cyclic G is carbocycle, or heterocyclyl each optionally substituted by one to two R8; R1 is hydrogen, C1-6 alkyl or C 1-6 alkoxyC1-6 alkyl. Also disclosed are compositions, methods of making and using compounds of the formula (I).

INDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS

Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.