1194374-23-6Relevant articles and documents
Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity
Qian, Yong,Schürmann, Marc,Janning, Petra,Hedberg, Christian,Waldmann, Herbert
, p. 7766 - 7771 (2016)
Woodward's reagent K (WRK) is a reactive heterocyclic compound that has been employed in protein chemistry to covalently and unspecifically label proteins at nucleophilic amino acids, notably at histidine and cysteine. We have developed a panel of WRK-der
Harnessing Stereospecific Z-Enamides through Silver-Free Cp?Rh(III) Catalysis by Using Isoxazoles as Masked Electrophiles
Debbarma, Suvankar,Bera, Sourav Sekhar,Maji, Modhu Sudan
supporting information, p. 835 - 839 (2019/01/26)
The stereospecific synthesis of Z-enamides is described in this paper. For the first time, isoxazoles have been employed as electrophiles in C-H functionalization to afford thermodynamically less stable Z-enamides utilizing salicylaldehydes in an atom- and step-economic fashion. The stereochemistry of enamides might originate from the relative disposition of atoms present in isoxazole and the intramolecular hydrogen bonding. The reaction showed excellent scope as several structurally and electronically diverse salicylaldehydes and isoxazoles reacted efficiently.
Gold(III)-catalyzed synthesis of isoxazoles by cycloisomerization of α,β-acetylenic oximes
Praveen,Kalyanasundaram,Perumal
experimental part, p. 777 - 781 (2010/06/12)
Cycloisomerization of,-acetylenic oximes leading to substituted isoxazoles was achieved using AuCl3 as catalyst, under moderate reaction conditions. The reaction can be applied to various acetylenic oximes and gives good to excellent yields. Th
