1194374-71-4

Basic information

• Product Name: methyl 5-fluoro-2-formylbenzoate
• Synonyms: methyl 5-fluoro-2-formylbenzoate;5-Fluoro-2-formyl-benzoic acid methyl ester;Benzoic acid, 5-fluoro-2-formyl-, methyl ester;methyl 2-formyl-5-fluorobenzoate
• CAS NO: 1194374-71-4
• Molecular Formula: C₉H₇FO₃
• Molecular Weight: 182.1484832
• Mol File: 1194374-71-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 294.8±30.0 °C(Predicted)
• Appearance: /
• Density: 1.271±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: methyl 5-fluoro-2-formylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-fluoro-2-formylbenzoate(1194374-71-4)
• EPA Substance Registry System: methyl 5-fluoro-2-formylbenzoate(1194374-71-4)

Safety Data

• Hazardous Substances Data: 1194374-71-4(Hazardous Substances Data)

Usage

General Description

Methyl 5-fluoro-2-formylbenzoate is a chemical compound with the molecular formula C9H7FO3. It is a white solid with a molecular weight of 182.15 g/mol. methyl 5-fluoro-2-formylbenzoate is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is a derivative of benzoic acid, with a fluorine atom and a formyl group attached to the benzene ring. Methyl 5-fluoro-2-formylbenzoate is known for its reactivity and can undergo various chemical reactions, making it a versatile compound for the production of a range of important molecules. Its properties make it an important intermediate in the chemical industry and in pharmaceutical research.

Upstream product

• 920481-01-2 5-fluoro-2-formylbenzoic acid 
• 74-88-4 methyl iodide 
• 394-28-5 2-Bromo-5-fluorobenzoic acid 
• 23932-84-5 6-fluoroisobenzofuran-1(3H)-one 
• 77-78-1 dimethyl sulfate 

Relevant articles and documents

Indium-Catalyzed C?F Bond Transformation through Oxymetalation/β-Fluorine Elimination to Access Fluorinated Isocoumarins

Fluorinated heterocycles have attracted much attention in the pharmaceutical and agrochemical industries. Many strategies have already been developed to achieve the synthesis of fluorinated heterocycles. Formidable challenges remain, however, in the synthesis of fluorinated isocoumarin derivatives that are among the most alluring structural motifs. Herein, the indium-catalyzed C?F bond transformation of 2-(2,2-difluorovinyl) benzoates is reported, which are readily accessible compounds, to give a diverse array of fluorinated isocoumarins. The present reaction proceeds smoothly using inexpensive reagents: a catalytic amount of indium salt in the presence of zinc salt. A theoretical calculation of potential energy profiles showed that the reaction consists of oxymetalation with the elimination of alkyl halide and the β-fluorine elimination.

Highly enantioselective synthesis of 2,3-dihydro-1 H-imidazo[2,1-a isoindol-5(9b H)-ones via catalytic asymmetric intramolecular cascade imidization-nucleophilic addition-lactamization

Highly enantioselective catalytic asymmetric intramolecular cascade imidization-nucleophilic addition-lactamization of N1-alkylethane-1,2-diamine with methyl 2-formylbenzoate catalyzed by a chiral phosphoric acid represents the first efficient method for the preparation of medicinally interesting chiral 2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-ones with high yields and excellent enantioselectivities. This strategy has been shown to be quite general toward various methyl 2-formylbenzoates.