1194486-65-1Relevant academic research and scientific papers
Enantioselective synthesis of fluorene derivatives by chiral N-triflyl phosphoramide catalyzed double Friedel-Crafts alkylation reaction
Wang, Shou-Guo,Han, Long,Zeng, Mi,Sun, Feng-Lai,Zhang, Wei,You, Shu-Li
, p. 3202 - 3209 (2012)
A highly efficient tandem double Friedel-Crafts reaction between indoles and 2-formylbiphenyl derivatives by chiral N-triflyl phosphoramide was realized. Under mild conditions, various 9-(3-indolyl) fluorene derivatives have been obtained in good yield and up to 94% ee. Comparing to their corresponding chiral phosphoric acids, chiral N-triflyl phosphoramides catalyzed reactions led to products with opposite absolute configuration.
Enantioselective synthesis of fluorene derivatives by chiral phosphoric acid catalyzed tandem double friedel-crafts reaction
Sun, Feng-Lai,Zeng, Mi,Gu, Qing,You, Shu-Li
supporting information; experimental part, p. 8709 - 8712 (2010/03/24)
A tandem double Friedel Crafts reaction of indoles with 2-formylbiphenyls, leading to 9-(3-indolyl) fluorene derivatives with up to 96% ee was reported. Several solvents, namely, benzene, dichioromethane, and carbon tetrachloride, were screened and the us
