119451-89-7Relevant academic research and scientific papers
(tert-Butyldimethylsilyloxy)methyl Chloride: Synthesis and Use as N-protecting Group in Pyrimidinones
Benneche, Tore,Gundersen, Lise-Lotte,Undheim, Kjell
, p. 384 - 389 (2007/10/02)
A new reagent, (tert-butyldimethylsilyloxy)methyl chloride (3) has been synthesized by sulfuryl chloride cleavage of (tert-butyldimethylsilyloxy)methyl ethyl sulfide (2).The latter was prepared from tert-butyldimethylsilyl chloride and ethylthiomethanol.The chloromethyl ether 3 has been used for the protection of the NH functionality in 5-halo-2(1H)-pyrimidinones and for the protection of the N-1 in N-3 alkylation of thymine.
