1194550-59-8

Basic information

• Product Name: benzyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate
• Synonyms: benzyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate;(S)-benzyl 2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride;(S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate;L-Phenylalanine, 3-(methylsulfonyl)-, phenylmethyl ester, hydrochloride (1:1);3-(Methylsulfonyl)-L-phenylalanine phenylmethyl ester hydrochloride (1:1);(S)-benzyl 2-amino-3-(3-(methyl;benzyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride;Lifitegrast Intermediate 4
• CAS NO: 1194550-59-8
• Molecular Formula: C₁₇H₁₉NO₄S*ClH
• Molecular Weight: 333.40206
• EINECS: -0
• Mol File: 1194550-59-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: benzyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate(1194550-59-8)
• EPA Substance Registry System: benzyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate(1194550-59-8)

Safety Data

• Hazardous Substances Data: 1194550-59-8(Hazardous Substances Data)

Usage

Uses

(S)-Benzyl 2-Amino-3-(3-(methylsulfonyl)phenyl)propanoate Hydrochloride is a reagent in the development of potent LFA-1/ICAM antagonist SAR 118 as an opthalmic solution for treating dry eyes. Preparation of crystalline isoquinoline derivative as LFA-1 inhibitors.

Upstream product

• 82311-69-1 (S)-2-amino-3-(3-bromophenyl)propanoic acid 
• 1289646-78-1 (S)-benzyl 2-((tert-butoxycarbonyl)amino)-3-((3-methylsulfonyl)phenyl)propionate 
• 1289646-76-9 (S)-2-((tert-butoxycarbonyl)amino)-3-((3-methylsulfonyl)phenyl)propanol 
• 82278-73-7 (2S)-3-(3-bromophenyl)-2-[(tert-butoxycarbonyl)amino]propanoic acid 

Downstream Products

• 1194550-65-6 benzyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-[3-(methylsulfonyl)phenyl]propanoate hydrochloride 
• 1194550-67-8 ((S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-methylsulfonyl)phenyl)propanoate 
• 1025967-78-5 (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid 
• 1194550-63-4 C₄₆H₄₀Cl₂N₂O₅S 
• 1194550-61-2 benzyl (S)-2-[2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido]-3-[3-(methylsulfonyl)phenyl]propanoate 

Relevant articles and documents

LFA-1 INHIBITOR AND POLYMORPH THEREOF

Methods of preparation and purification of a compound, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA -1 mediated diseases are also disclosed.