1194687-48-3

Basic information

• Product Name: 6-chloro-N-(2-methylbenzyl)pyrazine-2-carboxamide
• Synonyms: 6-chloro-N-(2-methylbenzyl)pyrazine-2-carboxamide
• CAS NO: 1194687-48-3
• Molecular Weight: 261.711
• Mol File: 1194687-48-3.mol

Chemical Properties

• CAS DataBase Reference: 6-chloro-N-(2-methylbenzyl)pyrazine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-N-(2-methylbenzyl)pyrazine-2-carboxamide(1194687-48-3)
• EPA Substance Registry System: 6-chloro-N-(2-methylbenzyl)pyrazine-2-carboxamide(1194687-48-3)

Safety Data

• Hazardous Substances Data: 1194687-48-3(Hazardous Substances Data)

Usage

Structure

contains a chloro group and a 2-methylbenzyl group
Commonly used in pharmaceutical industry
Used for synthesis of potential drug candidates
Suitable for molecular modification and structure-activity relationship studies in medicinal chemistry
Potential applications in organic synthesis and chemical research

Upstream product

• 770-00-3 methylester of pyrazinecarboxylic acid 4-oxide 
• 6164-79-0 methyl pyrazine-2-carboxylate 
• 89-93-0 ortho-methylbenzylamine 
• 23611-75-8 6-chloro-pyrazine-2-carboxylic acid methyl ester 

Downstream Products

• 1194687-49-4 (3aR,6aS)-tert-butyl 5-(6-(2-methylbenzylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1194687-56-3 (3aR,6aR)-tert-butyl 1-(6-(2-methylbenzylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate 
• 1194687-55-2 6-((3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-N-(2-methylbenzyl)pyrazine-2-carboxamide 
• 1194687-52-9 6-((3aS,6aS)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)-N-(2-methylbenzyl)pyrazine-2-carboxamide 
• 1338832-93-1 6-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-N-(2-methylbenzyl)pyrazine-2-carboxamide trifluoroacetate 

Relevant articles and documents

Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as Potent α4β2 nicotinic acetylcholine receptor ligands

A series of diazabicyclo[3.3.0]octane substituted pyridines and pyrazines was synthesized and characterized at the α4β2 neuronal nicotinic acetylcholine receptor (nAChR). The compounds were designed to mimic the profile of ABT-089, high affinity binding ligand for the α4β2 nAChR, with limited agonist activity. Carboxamide derivatives of 3-(diazabicyclo[3.3.0] octane)-substituted pyridines or 2-(diazabicyclo[3.3.0]octane)-substituted pyrazines were found to have the desired binding and activity profile. The structure-activity relationship of these compounds is presented.

Selective Ligands for the Neuronal Nicotinic Receptors and Uses Thereof

The present application describes selective ligands of formula (I) for neuronal nicotinic receptors (NNRs), more specifically for the α4β2 NNR subtype, compositions thereof, and methods of using the same, wherein X, R1, X, R2, R3, L1, m, n, p, and q are defined in the specification.