1194765-46-2Relevant academic research and scientific papers
New halogenated tris-(phenylalkyl)amines as h5-HT2Breceptor ligands
Kapadia, Nirav,Ahmed, Shahrear,Harding, Wayne W.
, p. 3216 - 3219 (2016)
A series of compounds in which various halogen substituents were incorporated into a phenyl ring of a tris-(phenylalkyl)amine scaffold, was synthesized and evaluated for affinity to h5-HT2receptors. In general, all compounds were found to have
Identification of tris-(phenylalkyl)amines as new selective h5-HT2B receptor antagonists
Ponnala, Shashikanth,Kapadia, Nirav,Harding, Wayne Wesley
, p. 601 - 605 (2015/04/27)
A series of tris-(phenylalkyl)amines was synthesized and evaluated for affinity to human 5-HT2 receptors. In general, the compounds displayed high affinity (4 of 11 analogs had Ki values 2B receptor vs. other 5-HT2 receptors. Functional assays revealed that the compounds are 5-HT2B antagonists. This journal is
(±)-Nantenine analogs as antagonists at human 5-HT2A receptors: C1 and flexible congeners
Chaudhary, Sandeep,Pecic, Stevan,LeGendre, Onica,Navarro, Hérnan A.,Harding, Wayne W.
scheme or table, p. 2530 - 2532 (2009/12/25)
C1 and flexible analogs of (±)-nantenine were synthesized and evaluated for antagonist activity at human 5-HT2A receptors in a calcium mobilization assay. This work has resulted in the identification of the most potent 5-HT2A antagon
