119478-55-6

Basic information

• Product Name: Danofloxacin mesylate
• Synonyms: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-, methanesulfonate (1:1);Mesylate Dan Nuosha star;1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-quinolin-3-carboxylic acid methanesulfonate (1:1);DANOFLOXACIN MESILATE;DANOFLOXACIN MESULATE;DANOFLOXACIN MESYLATE;DANOFLOXANCIN MESYLATE;1-cyclopropyl-6-fluoro-7-[(1s,4s)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid monomethanesulfonate
• CAS NO: 119478-55-6
• Molecular Formula: C20H24FN3O6S
• Molecular Weight: 453.48
• EINECS: 1806241-263-5
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 119478-55-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 337-339°C
• Boiling Point: 569.3 °C at 760 mmHg
• Flash Point: 298.1 °C
• Appearance: Crystalline solid
• Vapor Pressure: 8.41E-14mmHg at 25°C
• Storage Temp.: 0-6°C
• Solubility: Aqueous Base (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slight
• Stability: Hygroscopic
• CAS DataBase Reference: Danofloxacin mesylate(CAS DataBase Reference)
• NIST Chemistry Reference: Danofloxacin mesylate(119478-55-6)
• EPA Substance Registry System: Danofloxacin mesylate(119478-55-6)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 119478-55-6(Hazardous Substances Data)

Usage

Description

Different sources of media describe the Description of 119478-55-6 differently. You can refer to the following data:
1. Danofloxacin is a fluoroquinolone antibiotic and a type II topoisomerase inhibitor. It has a broad antimicrobial spectrum. It can be used as an anti-infective agent for veterinary use only.
2. Danofloxacin is a fluoroquinolone antibiotic. In vitro, danofloxacin has activity against 68 field isolates of Mycoplasma species isolated from cattle, swine, and poultry with MICs ranging from 8 to 500 nM. It is protective in vivo against P. multocida, E. coli, and S. choleraesuis in mice with protective doses of 0.31, 0.40, and 2.42 mg/kg, respectively. Formulations containing danofloxacin are widely used to prevent infectious disease in livestock.

Brand Name(s) in US

Advocin

Reference

J. A. Schrickx, J. Fink-Gremmels, Danofloxacin-mesylate is a substrate for ATP-dependent efflux transporters, British Journal of Pharmacology, 2009, vol. 150, pp. 463-469

Chemical Properties

Crystalline Solid

Uses

Different sources of media describe the Uses of 119478-55-6 differently. You can refer to the following data:
1. Fluorinated quinolone antibacterial
2. Danofloxacin is a fluoroquinolone antibacterial for veterinary use, with MIC90 of 0.28 μM
3. Fluorinated quinolone antibacterial.

Veterinary Drugs and Treatments

Danofloxacin mesylate injection is indicated for the treatment of Bovine Respiratory Disease (BRD) associated with Mannheimia (Pasturella) hemolytica and P. multocida in cattle (not dairy or veal). Because of the drug’s spectrum of activity, it may also be of benefit in the treatment of infections caused by Histophilus somni (Haemophilus somnus) or M. bovis, but the drug is not labeled (at the time of writing) for treating these pathogens. In other countries, danofloxacin may be labeled for use in swine and chickens (non-laying), but in the USA it is illegal to use the drug in an extralabel manner in food-producing species. Danofloxacin may be of benefit in treating susceptible infections in adult horses, camelids and other non-food producing species.

InChI:InChI=1/C19H20FN3O3.CH4O3S/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10;1-5(2,3)4/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26);1H3,(H,2,3,4)/t11-,12-;/m0./s1

Synthetic route

Advocin (119478-55-6) → carbon dioxide (124-38-9) + water (7732-18-5)

Conditions	Yield
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