119497-03-9Relevant articles and documents
Pyrazoleamidine compounds
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, (2008/06/13)
A process for the production of guanidino protected ω-aminoalkyl guanidines comprising reacting a diamine selectively at one amino group with an alkoxycarbonyl or aralkoxycarbonyl protected electrophilic guanylation reagent. The process of the invention i
Synthetic GHRH analogs
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, (2008/06/13)
Human pancreatic GRF (hpGRF), rat hypothalamic GRF (rGRF) and porcine hypothalamic GRF (pGRF) have been earlier characterized and synthesized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in animals, including humans, which have resistance to enzymatic degradation in the body, and which have the sequence: STR1 wherein Q1 is an omega or alpha-omega substituted alkyl, Q2 is a lower omega-quanidino-alkyl group. R2 is Ala, D-Ala, or D-N-Methyl-Ala R3 is Asp, D-Asp, Glu, or D-Glu R8 is Asn, D-Asn, Ser, or D-Ser R10 is Tyr or D-Tyr R12 is Lys, D-Lys Arg or Orn R13 is Val or Ile R14 is Leu or D-Leu R15 is Gly, N-Methyl-Gly, or D-Ala R17 is Leu or D-Leu R18 is Tyr or Ser R23 is Leu or D-Leu R24 is Gln or His R25 is Asp, D-Asp, Glu, or D-Glu R27 is Met, D-Met, Ala, Nle, Ile, Val, Nva, Leu R28 is Asn or Ser The peptides as well as nontoxic salts thereof may be administered to animals, including humans and cold-blooded animals, to stimulate the release of GH and may be used diagnostically.
