1195007-09-0

Basic information

• Product Name: 2'-EE-7,10-di-Boc-paclitaxel
• Synonyms: 2'-EE-7,10-di-Boc-paclitaxel
• CAS NO: 1195007-09-0
• Molecular Weight: 1084.22
• Mol File: 1195007-09-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-EE-7,10-di-Boc-paclitaxel(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-EE-7,10-di-Boc-paclitaxel(1195007-09-0)
• EPA Substance Registry System: 2'-EE-7,10-di-Boc-paclitaxel(1195007-09-0)

Safety Data

• Hazardous Substances Data: 1195007-09-0(Hazardous Substances Data)

Upstream product

• 1195007-11-4 7,10-di-tert-butoxycarbonyl-baccatin III 
• 201856-53-3 (3R,4S)-3-(1-ethoxyethoxy)-4-(phenyl)-N-benzoyl-2-azetidinone 

Relevant articles and documents

PROCESSES FOR PREPARATION OF TAXANES AND INTERMEDIATES THEREOF

A paclitaxel intermediate of formula 1: wherein R1 is acetyl, R2 is tert-butyloxycarbonyl (BOC), R3 and R4 are phenyl and R5 is 1-ethoxyethyl, is provided. Also provided are processes for preparing taxane intermediates of formula 1 comprising reacting a compound of formula 2 with a compound of formula 3 wherein, R1, R2 and R5 are independently a hydroxyl protecting group; R3 is phenyl, substituted phenyl, a straight or branched alkyl containing 1 to 12 carbon atoms, alkenyl containing 2 to 12 carbon atoms, cycloalkyl containing 4 to 15 carbon atoms, cycloalkenyl or an R6—O— group in which R6 is: phenyl, substituted phenyl group, a C1-C8 straight or branched alkyl, a C2-C8 straight or branched alkenyl group, a C3-C8 straight or branched alkynyl, a C3-C7 cycloalkyl, C4-C7 cycloalkenyl, a C7-C11 bicycloalkyl substituent, or a saturated or unsaturated nitrogen; and R4 is phenyl or a substituted phenyl group.