1195072-76-4

Upstream product

• 109-04-6 2-bromo-pyridine 
• 98-80-6 phenylboronic acid 
• 1008-89-5 2-phenylpyridine 
• 1245636-12-7 2-(5-bromo-2-chlorophenyl)pyridine 
• 55-21-0 benzamide 
• 4373-60-8 2-(3-bromophenyl)pyridine 

Downstream Products

• 879085-55-9 vismodegib 
• 879088-41-2 4-chloro-3-(pyridin-2-yl)benzeneamine 

Relevant academic research and scientific papers

2 - chloro - N - (4 - chloro - 3 - (2 - pyridyl) phenyl) - 4 - methyl sulphone phenyl benzamide preparation method

The invention discloses a preparation method of 2-chlorine-N-(4-chlorine-3-(2-pyridyl)phenyl)-4-methyl sulfone phenyl benzamide. The reaction formula is as shown in the specification. The method disclosed by the invention has the advantages that the opera

Directed meta-Selective Bromination of Arenes with Ruthenium Catalysts

A Ru-catalyzed direct C?H activation/meta-bromination of arenes bearing pyridyl, pyrimidyl, and pyrazolyl directing groups has been developed. A series of bromo aryl pyridines and pyrimidines have been synthesized, and further coupling reactions have also been demonstrated for a number of representative functionalized arenes. Preliminary mechanistic studies have revealed that this reaction may proceed through radical-mediated bromination when NBS is utilized as the bromine source. This type of transformation has opened up a new direction for the radical non-ipso functionalization of metal with regard to future C?H activation development that would allow the remote functionalization of aromatic systems.