1195100-15-2Relevant academic research and scientific papers
Synthesis of second-and third-generation asp oligopeptide conjugated dendrimers for bone-targeting drug delivery
Ouyang, Liang,Pan, Junzhu,Zhang, Yu,Guo, Li
body text, p. 4039 - 4052 (2010/02/27)
The second-and third-generation multiple dendrimers based on naproxen in core and Asp(4-6) oligopeptides in periphery were synthesized in a convergent approach and well characterized by NMR and mass spectral (MS) techniques. These conjugates showed a high affinity to hydroxyapatite in vitro and provided an effective entry for the synthesis of a peptide dendrimer used for bone targeting.
Bone targeting prodrugs based on peptide dendrimers, synthesis and hydroxyapatite binding in vitro
Ouyanga, Liang,Huang, Wencai,Hea, Gu,Guo, Li
experimental part, p. 272 - 277 (2010/04/23)
Novel bone targeting naproxen prodrugs with poly(aspartic acid) moieties and with two and three poly(aspartic acid) sequences peptide dendrimers were synthesized using a conventional method. The modified naproxen conjugates were incubated with hydroxyapatite in PBS at physiological conditions over 16h. The study revealed the hydroxyapatite binding properties of poly(aspartic acid) and it was found that the peptide dendrimer prodrugs exhibited a faster initial binding and a greater total binding. The obtained binding data in vitro indicated that the peptide dendrimers with poly(aspartic acid) sequences were useful for the development of new bone targeting molecules for drug delivery to bone.
