1195110-33-8

Basic information

• Product Name: 4-(4-phenyl-5-(3-phenyl-5-(4-prop-2-ynyloxyphenyl)pyrrol-2-ylideneamino)-1H-pyrrol-2-yl)phenol, BF₂ chelate
• Synonyms: 4-(4-phenyl-5-(3-phenyl-5-(4-prop-2-ynyloxyphenyl)pyrrol-2-ylideneamino)-1H-pyrrol-2-yl)phenol, BF₂ chelate
• CAS NO: 1195110-33-8
• Molecular Weight: 567.402
• Mol File: 1195110-33-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-(4-phenyl-5-(3-phenyl-5-(4-prop-2-ynyloxyphenyl)pyrrol-2-ylideneamino)-1H-pyrrol-2-yl)phenol, BF₂ chelate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-phenyl-5-(3-phenyl-5-(4-prop-2-ynyloxyphenyl)pyrrol-2-ylideneamino)-1H-pyrrol-2-yl)phenol, BF₂ chelate(1195110-33-8)
• EPA Substance Registry System: 4-(4-phenyl-5-(3-phenyl-5-(4-prop-2-ynyloxyphenyl)pyrrol-2-ylideneamino)-1H-pyrrol-2-yl)phenol, BF₂ chelate(1195110-33-8)

Safety Data

• Hazardous Substances Data: 1195110-33-8(Hazardous Substances Data)

Upstream product

• 6165-76-0 propargyl p-toluenesulfonate 
• 1195110-34-9 4,4'-(5,5-difluoro-1,9-diphenyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,5,2]triazaborinine-3,7-diyl)diphenol 
• 1093881-86-7 1-(4-hydroxyphenyl)-4-nitro-3-phenylbutan-1-one 
• 2657-25-2 4'-hydroxychalcone 
• 106-96-7 propargyl bromide 
• 1194952-47-0 [5-(4-hydroxyphenyl)-3-phenyl-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-phenylpyrrol-2-ylidene]-amine 

Downstream Products

• 1195110-37-2 4-[4-(4-{5-[5-(4-hydroxyphenyl)-3-phenyl-1H-pyrrol-2-ylimino]-4-phenyl-5H-pyrrol-2-yl}phenoxymethyl)-[1,2,3]triazol-1-yl]butyric acid , BF₂ chelate 
• 1195110-38-3 {2-[4-(4-{5-[5-(4-hydroxyphenyl)-3-phenyl-7H-pyrrol-2-ylimino]-4-phenyl-5H-pyrrol-2-yl}-phenoxymethyl)-[l,2,3]triazol-l-yl]ethyl}carbamic acid t-butyl ester, BF₂ chelate 

Relevant articles and documents

Fluorescent and Water Dispersible Single-Chain Nanoparticles: Core–Shell Structured Compartmentation

Single-chain nanoparticles (SCNPs) are highly versatile structures resembling proteins, able to function as catalysts or biomedical delivery systems. Based on their synthesis by single-chain collapse into nanoparticular systems, their internal structure is complex, resulting in nanosized domains preformed during the crosslinking process. In this study we present proof of such nanocompartments within SCNPs via a combination of electron paramagnetic resonance (EPR) and fluorescence spectroscopy. A novel strategy to encapsulate labels within these water dispersible SCNPs with hydrodynamic radii of ≈5 nm is presented, based on amphiphilic polymers with additional covalently bound labels, attached via the copper catalyzed azide/alkyne “click” reaction (CuAAC). A detailed profile of the interior of the SCNPs and the labels’ microenvironment was obtained via electron paramagnetic resonance (EPR) experiments, followed by an assessment of their photophysical properties.

A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells

We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug 6 in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug 6 is able to monitor drug delivery and cellular imaging.

FLUORESCENT NEAR INFRA-RED (NIR) DYES

A compound of formula (I) is described in which each A, which may be the same or different, is a halide selected from fluoride, chloride, bromide and iodide, or is O-Y, wherein Y is a substituted or unsubstituted, saturated or unsaturated, straight or branched chain alkyl moiety. R1, R2, R3, R6, R7, and R8 are each independently H, OH, NO2 or O-L-X, wherein L is a spacer group, and X is a conjugation group or a water- solubilizing group. At least one of R1, R2, R3 is OH or O-L-X and at least one of R6, R7, and R8 is OH or O-L-X. R4 and R5, which may be the same or different, are each independently H; or are a substituted or unsubstituted, saturated or unsaturated, cyclic moiety; a substituted or unsubstituted, saturated or unsaturated heterocyclic moiety; or a substituted or unsubstituted, saturated or unsaturated, straight or branched chain alkyl moiety. Also described are dye conjugates comprising a compound of the invention.