119520-49-9

Upstream product

• 119541-41-2 3-Phenyl-N-pyridin-3-yl-thiopropionimidic acid pyridin-2-yl ester 
• 28048-94-4 2-methylpropyl 3-phenypropionate 
• 119520-57-9 N-(4-nitrophenyl)-3-phenylpropionamide 
• 462-08-8 pyridin-3-ylamine 
• 2021-28-5 ethyl dihydrocinnamate 
• 501-52-0 3-Phenylpropionic acid 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 645-45-4 hydrocinnamic acid chloride 
• 119520-61-5 3-phenylpropanoic dithioperoxyanhydride 
• 119520-57-9 N-(4-nitrophenyl)-3-phenylpropionamide 
• 114050-31-6 3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester 
• 28048-94-4 2-methylpropyl 3-phenypropionate 
• 501-52-0 3-Phenylpropionic acid 
• 77078-54-7 3-phenylthiopropionic acid 

Relevant academic research and scientific papers

Boric Acid Catalyzed Direct Amidation between Amino-Azaarenes and Carboxylic Acids

A novel and facile boric acid catalyzed direct amidation between amino-azaarene compounds and carboxylic acids has been developed. The amidation proceeded cleanly and provided good to excellent yields of the desired amides. Boric acid is a green and inexpensive catalyst. We have also found that N,N,N′,N′-tetramethylpropane-1,3-diamine acted as an additive accelerating this boric acid catalyzed amidation. A mixed acid anhydride is postulated to be the active intermediate responsible for this successful amidation. This direct amidation is an atom- and step-economical reaction.

Tert-butoxide-assisted amidation of esters under green conditions

Efficient and green amidation reactions are of great importance. In this work, we demonstrate the tert-butoxide-assisted amidation of esters with amines under ambient conditions. Aliphatic and/or aromatic esters were converted into the corresponding amides under mild conditions in good to excellent yields. It is noteworthy that the reaction is highly efficient, rapid, versatile, green and economical, and will find great practical application in organic synthesis, biochemistry, and industrial chemistry. Georg Thieme Verlag Stuttgart. New York.

THE INVENTION OF RADICAL REACTIONS PART XVIII. A CONVENIENT SOLUTION TO THE 1-CARBON PROBLEM (R-CO2H --> R-13CO2H)

Radicals generated by photolysis (W light) of esters derived from N-hydroxy-2-thiopyridone react with electrophilic isocyanides 2a and (in the presence of trifluoroacetic acid) 2b to give adducts of type 3.Convenient reaction procedures have been worked out to hydrolyse the adducts to amides of type 5, from which the original acid can be regenerated under mild conditions.The three important acids oleic, linoleic and arachidonic have all given smooth reactions.In suitable examples, quantitative evolution of carbon dioxide and incorporation of 13C without dilution have been demonstrated.This reaction sequence will be useful for the labelling in the carboxyl group of prostaglandins, leukotrienes, and the side chain carboxyls of peptides.