119595-00-5

Upstream product

• 7500-58-5 trans-4,5-bis(hydroxymethyl)cyclohexene bis(toluene-p-sulfonate) 
• 20246-03-1 (1R,2R)-bis<(p-toluenesulfonyloxy)methyl>-4-cyclohexene 
• 143-33-9 sodium cyanide 

Downstream Products

• 119595-01-6 trans-4,5-bis(carboxymethyl)cyclohexene 
• 41065-46-7 (+/-)-2-Amino-3-cyan-3ar,4,7,7at-tetrahydro-1H-inden 
• 3716-38-9 (+/-)-trans-bicyclo<4.3.0>nonan-3β-ol 

Relevant academic research and scientific papers

[6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES

The present invention relates to the new [6+5] fused bicycle derivatives, pharmaceutically acceptable salts or isomers thereof, processes for preparing the same, and pharmaceutical compositions comprising the same. The [6+5] fused bicycle derivatives can antagonize the thrombin receptor and thus may be effectively used for the treatment and prevention of thrombus, platelet aggregation, atherosclerosis, restenosis, blood coagulation, hypertension, arrhythmia, angina pectoris, heart failure, inflammation and cancer when used alone or with other cardiovascular agents.

Enzymes in Organic Synthesis. 46. Regiospecific and Stereoselective Horse Liver Alcohol Dehydrogenase Catalyzed Reductions of cis- and trans-Bicyclononanones

Further evidence for the preference of horse liver alcohol dehydrogenase for six-membered rather than five-membered ring ketone substrates is presented.This chemospecificity can be exploited preparatively, as illustrated by the HLADH-catalyzed reductions