1195986-35-6Relevant articles and documents
Magnetic graphene oxide anchored sulfonic acid as a novel nanocatalyst for the synthesis of N-aryl-2-amino-1,6-naphthyridines
Rostamizadeh, Shahnaz,Rezgi, Mina,Shadjou, Nasrin,Hasanzadeh, Mohammad
, p. 1317 - 1322 (2014/04/17)
Magnetic graphene oxide functionalized with sulfonic acid (Fe 3O4-GO-SO3H) was used as a new recyclable nanocatalyst for one-pot synthesis of N-aryl-2-amino-1,6-naphthyridine derivatives under solvent free conditions. The catalyst could be easily recovered from the reaction mixture by an external magnet and reused without significant decrease in activity even after 4 runs. This nanocatalyst exhibited better activities to other commercially available sulfonic acid catalysts.
Diversity synthesis of N-substituted 2-amino-l,6-naphthyridine derivatives under microwave irradiation
Han, Zheng-Guo,Miao, Chun-Bao,Shi, Feng,Ning, Ma.,Zhang, Ge,Tu, Shu-Jiang
scheme or table, p. 16 - 19 (2010/10/04)
A sequential three-component reaction of 3, 5-diarylidenepiperidm-4-one, malononitrile, and amine (such as aromatic amine, cyclopropanamine, and NH 4OAc) in acetic acid under microwave irradiation has been developed. In this one-pot reaction, a series of new N-substituted 2-amino-l, 6-naphthyridine derivatives were synthesized with excellent yields. This method has the advantages of operational simplicity and increased safety for small-scale fast synthesis of N-aryl 2-amino-l, 6-naphthyridines for biomedical screening.