1196-69-6Relevant articles and documents
Palladium-Catalyzed Reductive Carbonylation of (Hetero) Aryl Halides and Triflates Using Cobalt Carbonyl as CO Source
Dogga, Bhushanarao,Joseph, Jayan T.,Kumar, C. S. Ananda
supporting information, p. 309 - 313 (2020/12/23)
An efficient protocol for the reductive carbonylation of (hetero) aryl halides and triflates under CO gas-free conditions using Pd/Co2(CO)8 and triethylsilane has been developed. The mild reaction conditions, enhanced chemoselectivity and, easy access to heterocyclic and vinyl carboxaldehydes highlights its importance in organic synthesis.
Decarboxylative formylation of aryl halides with glyoxylic acid by palladium catalysis under oxygen
Cao, Hualiang,Pu, Weiwen,Zhang, Jie,Yan, Peijun,Zhang, Jun,Xu, Sheng
supporting information, p. 1287 - 1290 (2020/08/21)
A new free radical/palladium cooperative catalyzed formylation of aryl halides with glyoxylic acid as the formyl source under oxygen conditions has been developed. Various aromatic and heteroaromatic aldehydes were produced in medium to good yields.
Synthesis method of 5-formylindole
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Paragraph 0011; 0016-0023, (2020/02/10)
The invention discloses a synthesis method of formylindole. The synthesis method comprises the following processing steps: S1, dissolving the raw material indole in a solvent at room temperature, carrying out heating to 35-45 DEG C, and completely dissolving the raw material; and S2, slowly adding a catalyst into a mixed solvent of indole and ethyl formate, carrying out refluxing at 45-55 DEG C for 5-48 h, and performing cooling, crystallizing and filtering to obtain 5-formylindole, wherein the solvent used in the step S1 is one or more selected from the group consisting of methyl formate, ethyl formate, propyl formate and butyl formate, and the use amount of the solvent in the step S1 is 4-10 times the mass of indole. The method is mild in reaction, simple to operate, high in final product yield and good in quality.