1196131-62-0

Basic information

• Product Name: 2-(4-fluorophenyl)-1H-benzimidazole-5,6-dicarbonitrile
• Synonyms: 2-(4-fluorophenyl)-1H-benzimidazole-5,6-dicarbonitrile
• CAS NO: 1196131-62-0
• Molecular Weight: 262.246
• Mol File: 1196131-62-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-1H-benzimidazole-5,6-dicarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-1H-benzimidazole-5,6-dicarbonitrile(1196131-62-0)
• EPA Substance Registry System: 2-(4-fluorophenyl)-1H-benzimidazole-5,6-dicarbonitrile(1196131-62-0)

Safety Data

• Hazardous Substances Data: 1196131-62-0(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 129365-93-1 4,5-diaminophthalonitrile 

Downstream Products

• 1196131-67-5 1-butyl-2-(4-fluorophenyl)-1H-benzimidazole-5,6-dicarbonitrile 

Relevant articles and documents

FLUORESCENCE LABELING AGENT, PHOTODYNAMIC THERAPEUTIC AGENT AND PHTHALOCYANINE

PROBLEM TO BE SOLVED: To provide a phthalocyanine-based compound having excellent properties such as fluorescence intensity, light resistance and singlet oxygen generation ability suitable for a fluorescence labeling agent and a photodynamic therapeutic agent in a wavelength region of 800 nm or more. SOLUTION: This invention relates to salts of a phosphorus-containing phthalocyanine-based compound in which a phosphorus atom in a phosphorus compound expressed by formula: R5O-P-OR6 is coordinated with a phthalocyanine-based compound, and to a fluorescence labeling agent and a photodynamic therapeutic agent, which contain the salts of the phosphorus-containing phthalocyanine-based compound. In the formula, R5 and R6 are H, an aliphatic hydrocarbon group, -P(=O) R7R8, -C(=O) R9, -S(=O)2R10 or -SiR11R12R13; R7 and R8 are H, OH, an aliphatic hydrocarbon group, an aromatic hydrocarbon group, an alkoxyl group, or an aryloxy group; R9 is H, an aliphatic hydrocarbon group, or an aromatic hydrocarbon group; R10 is OH, an aliphatic hydrocarbon group, or an aromatic hydrocarbon group; and R11 to R13 are an aliphatic hydrocarbon group or an aromatic hydrocarbon group. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles

(Chemical Equation Presented) A series of 47 novel N1-alkylated- 2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 μg/mL. Indole analogues 108-110 have no inhibitory activity.