1196453-99-2Relevant academic research and scientific papers
Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophore
Wang, Yuesheng,Jones, Paulianda J.,Batts, Timothy W.,Landry, Victoria,Patel, Manoj K.,Brown, Milton L.
, p. 7064 - 7072 (2009)
The voltage-gated sodium channel remains a rich area for the development of novel blockers. In this study we used comparative molecular field analysis (CoMFA), a ligand-based design strategy, to generate a 3D model based upon local anesthetics, hydantoins
